Efficacy and Safety Assessment of T. Angelica Herbal Tonic, a Phytomedicinal Product Popularly Used in Nigeria
Joint Authors
Nworu, Chukwuemeka S.
Esimone, Charles O.
Akah, Peter A.
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-03-09
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
T.
Angelica Herbal Tonic (TAHT) is a herbal product indicated for indigestion and constipation and highly patronized in Nigeria.
In this study, the efficacy and safety of the herbal tonic in relation to the label claims were assessed.
The effect on peristalsis in mice was evaluated by the charcoal meal model and in vitro using guinea pig ileum.
The effects of TAHT on behavior, fertility, birth and organ weights were also determined.
Teratogenic potential and reproductive toxicity were studied in pregnant rats.
Acute toxicity studies showed that at doses above 5000 mg kg−1, the herbal tonic did not cause lethality and produced no signs of intoxication in mice.
The study did not show any gross behavioral changes in mice treated with 1000 mg kg−1 of TAHT as compared with the negative control treatment.
TAHT (400 mg kg−1) exhibited a dose-dependent enhancement in the gastrointestinal tract motility in mice when compared with the negative control.
At concentrations up to 300 μg mL−1, TAHT did not cause any significant effect on acetylcholine, histamine and nicotine-evoked contractions of guinea pig ileum preparation.
It took an average of 31.25 ± 4.52 days for the TAHT-treated animals to litter, which is significantly (P < .05) different from the 55 ± 4.51 days recorded for the control treatment group.
TAHT exhibited a modest fertility-promoting effect and showed lack of abortifacient and teratogenic properties in the study.
Generally, the results of this study showed some favorable pharmacological effects of TAHT in animals which may authenticate some of the label claims.
American Psychological Association (APA)
Esimone, Charles O.& Akah, Peter A.& Nworu, Chukwuemeka S.. 2011. Efficacy and Safety Assessment of T. Angelica Herbal Tonic, a Phytomedicinal Product Popularly Used in Nigeria. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-447378
Modern Language Association (MLA)
Esimone, Charles O.…[et al.]. Efficacy and Safety Assessment of T. Angelica Herbal Tonic, a Phytomedicinal Product Popularly Used in Nigeria. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-447378
American Medical Association (AMA)
Esimone, Charles O.& Akah, Peter A.& Nworu, Chukwuemeka S.. Efficacy and Safety Assessment of T. Angelica Herbal Tonic, a Phytomedicinal Product Popularly Used in Nigeria. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-447378
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-447378