Peripheral Blood WT1 Expression Predicts Relapse in AML Patients Undergoing Allogeneic Stem Cell Transplantation
Joint Authors
Borlenghi, Erika
Turra, Alessandro
Perucca, Simone
Caimi, Luigi
Di Palma, Andrea
Alghisi, Elisa
Cattina, Federica
Rossi, Giuseppe
Cancelli, Valeria
Pagani, Chiara
Russo, Domenico
Malagola, Michele
Skert, Cristina
Ruggeri, Giuseppina
Ribolla, Rossella
Bernardi, Simona
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-17
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
To evaluate if WT1 expression may predict relapse after allo-SCT, we analyzed WT1 levels on peripheral blood (PB) and bone marrow (BM) before and after allo-SCT in 24 AML patients with WT1 overexpression at diagnosis.
Five copies of WT1/ABL × 104 from PB were identified as the threshold value that correlated with relapse after allo-SCT.
The same correlation was not identified when WT1 expression was assessed from bone marrow (BM).
Eight out of 11 (73%) patients with a pre-allo-SCT PB-WT1 ≥ 5 and 4/13 (31%) patients with a pre-allo-SCT PB-WT1 < 5 relapsed, respectively (P = 0.04).
The incidence of relapse was higher in patients with PB-WT1 ≥ 5 measured after allo-SCT, at the 3rd (56% versus 38%; P = 0.43) and at the 6th month (71% versus 20%; P = 0.03).
Patients with pretransplant PB-WT1 < 5 had significantly better 2-year OS and LFS than patients with a PB-WT1 ≥ 5 (81% versus 0% and 63% versus 20%) (P = 0.02).
Our data suggest the usefulness of WT1 monitoring from PB to predict the relapse in allotransplanted AML patients and to modulate the intensity of conditioning and/or the posttransplant immunosuppression in an attempt to reduce the posttransplant relapse risk.
American Psychological Association (APA)
Malagola, Michele& Skert, Cristina& Ruggeri, Giuseppina& Turra, Alessandro& Ribolla, Rossella& Cancelli, Valeria…[et al.]. 2014. Peripheral Blood WT1 Expression Predicts Relapse in AML Patients Undergoing Allogeneic Stem Cell Transplantation. BioMed Research International،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-447386
Modern Language Association (MLA)
Malagola, Michele…[et al.]. Peripheral Blood WT1 Expression Predicts Relapse in AML Patients Undergoing Allogeneic Stem Cell Transplantation. BioMed Research International No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-447386
American Medical Association (AMA)
Malagola, Michele& Skert, Cristina& Ruggeri, Giuseppina& Turra, Alessandro& Ribolla, Rossella& Cancelli, Valeria…[et al.]. Peripheral Blood WT1 Expression Predicts Relapse in AML Patients Undergoing Allogeneic Stem Cell Transplantation. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-447386
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-447386