Rituximab—A Drug with Many Facets and Cures : A Treatment for Acute Refractory Hypoxemic Respiratory Failure Secondary to Severe Granulomatosis with Polyangiitis
Joint Authors
Jamkhana, Zafar Akram
Powers, Braden
Gogineni, Sindhura
Uppalapati, Aditya
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-02-14
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Granulomatosis with Polyangiitis (GPA) is a rare systemic anti neutrophil cytoplasmic antibody (ANCA-) associated granulomatous vasculitis of the small and medium sized blood vessels.
Diffuse alveolar hemorrhage (DAH) is a rare life-threatening complication of GPA.
In our patient, cyclophosphamide was held secondary to complications of acute kidney injury, hematuria, and concern for a possible hemorrhagic cystitis.
However, during the workup for hematuria the patient acutely developed respiratory failure and was found to have DAH.
The patient was initially supported with mechanical ventilation volume control mode, steroids, and plasma exchange.
With no improvement of oxygenation, the mode of ventilation was changed to airway pressure release ventilation (APRV) and the patient was started on rituximab.
The patient clinically improved over the next few days, was able to be extubated, and was transferred out of the intensive care unit.
American Psychological Association (APA)
Powers, Braden& Uppalapati, Aditya& Gogineni, Sindhura& Jamkhana, Zafar Akram. 2013. Rituximab—A Drug with Many Facets and Cures : A Treatment for Acute Refractory Hypoxemic Respiratory Failure Secondary to Severe Granulomatosis with Polyangiitis. Case Reports in Critical Care،Vol. 2013, no. 2013, pp.1-4.
https://search.emarefa.net/detail/BIM-447394
Modern Language Association (MLA)
Powers, Braden…[et al.]. Rituximab—A Drug with Many Facets and Cures : A Treatment for Acute Refractory Hypoxemic Respiratory Failure Secondary to Severe Granulomatosis with Polyangiitis. Case Reports in Critical Care No. 2013 (2013), pp.1-4.
https://search.emarefa.net/detail/BIM-447394
American Medical Association (AMA)
Powers, Braden& Uppalapati, Aditya& Gogineni, Sindhura& Jamkhana, Zafar Akram. Rituximab—A Drug with Many Facets and Cures : A Treatment for Acute Refractory Hypoxemic Respiratory Failure Secondary to Severe Granulomatosis with Polyangiitis. Case Reports in Critical Care. 2013. Vol. 2013, no. 2013, pp.1-4.
https://search.emarefa.net/detail/BIM-447394
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-447394