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NPM-ALK : The Prototypic Member of a Family of Oncogenic Fusion Tyrosine Kinases
Joint Authors
Ingham, Robert J.
Lai, Raymond
Pearson, Joel D.
Lee, Jason K. H.
Bacani, Julinor T. C.
Source
Journal of Signal Transduction
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-18
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Anaplastic lymphoma kinase (ALK) was first identified in 1994 with the discovery that the gene encoding for this kinase was involved in the t(2;5)(p23;q35) chromosomal translocation observed in a subset of anaplastic large cell lymphoma (ALCL).
The NPM-ALK fusion protein generated by this translocation is a constitutively active tyrosine kinase, and much research has focused on characterizing the signalling pathways and cellular activities this oncoprotein regulates in ALCL.
We now know about the existence of nearly 20 distinct ALK translocation partners, and the fusion proteins resulting from these translocations play a critical role in the pathogenesis of a variety of cancers including subsets of large B-cell lymphomas, nonsmall cell lung carcinomas, and inflammatory myofibroblastic tumours.
Moreover, the inhibition of ALK has been shown to be an effective treatment strategy in some of these malignancies.
In this paper we will highlight malignancies where ALK translocations have been identified and discuss why ALK fusion proteins are constitutively active tyrosine kinases.
Finally, using ALCL as an example, we will examine three key signalling pathways activated by NPM-ALK that contribute to proliferation and survival in ALCL.
American Psychological Association (APA)
Pearson, Joel D.& Lee, Jason K. H.& Bacani, Julinor T. C.& Lai, Raymond& Ingham, Robert J.. 2012. NPM-ALK : The Prototypic Member of a Family of Oncogenic Fusion Tyrosine Kinases. Journal of Signal Transduction،Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-447401
Modern Language Association (MLA)
Pearson, Joel D.…[et al.]. NPM-ALK : The Prototypic Member of a Family of Oncogenic Fusion Tyrosine Kinases. Journal of Signal Transduction No. 2012 (2012), pp.1-14.
https://search.emarefa.net/detail/BIM-447401
American Medical Association (AMA)
Pearson, Joel D.& Lee, Jason K. H.& Bacani, Julinor T. C.& Lai, Raymond& Ingham, Robert J.. NPM-ALK : The Prototypic Member of a Family of Oncogenic Fusion Tyrosine Kinases. Journal of Signal Transduction. 2012. Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-447401
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-447401