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Periconceptional Undernutrition in Sheep Affects Adult Phenotype Only in Males
Joint Authors
Bloomfield, Frank H.
Honeyfield-Ross, Maggie
Harding, Jane E.
Oliver, Mark H.
Jaquiery, Anne L.
Source
Journal of Nutrition and Metabolism
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-02
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Periconceptional undernutrition (PCUN) in sheep alters fetal growth and metabolism and postnatal growth regulation, but effects on adult body composition are unknown.
We investigated the effects of PCUN on adult phenotype.
Singleton lambs of ewes fed normally (N, n=17) or undernourished before (UN-61-0 d, n=23), before and after (UN-61-30 d, n=19), or after (UN-2-30d, n=17) mating (d0) were weighed at birth, 12 weeks, and intermittently to adulthood.
At the age of 3-4 years, body composition was assessed by dual-emission X-ray absorptiometry followed by postmortem examination.
Compared with N animals, male, but not female, offspring of all UN groups had greater % fat mass (all UN versus N: 9±1 versus 2±1%, P<0.001) and perirenal fat (544±36 versus 222±44 g, P=0.002), and proportionately smaller hearts (4.5±0.1 versus 5.2±0.2 g·kg−1), lungs (9.1±0.2 versus 10.6±0.5 g·kg−1), and adrenals (0.06±0.002 versus 0.08±0.003 g·kg−1).
UN males also had larger testes (726±21 versus 545±32 g, P=0.007), but UN females had smaller ovaries (2.7±0.08 versus 3.4±0.4 g, P=0.01).
Changes were independent of birth weight or postnatal growth velocity.
Brief PCUN has sex-specific effects on adult phenotype, predominantly affecting males, which may contribute to adverse metabolic outcomes.
American Psychological Association (APA)
Jaquiery, Anne L.& Oliver, Mark H.& Honeyfield-Ross, Maggie& Harding, Jane E.& Bloomfield, Frank H.. 2012. Periconceptional Undernutrition in Sheep Affects Adult Phenotype Only in Males. Journal of Nutrition and Metabolism،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-447427
Modern Language Association (MLA)
Jaquiery, Anne L.…[et al.]. Periconceptional Undernutrition in Sheep Affects Adult Phenotype Only in Males. Journal of Nutrition and Metabolism No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-447427
American Medical Association (AMA)
Jaquiery, Anne L.& Oliver, Mark H.& Honeyfield-Ross, Maggie& Harding, Jane E.& Bloomfield, Frank H.. Periconceptional Undernutrition in Sheep Affects Adult Phenotype Only in Males. Journal of Nutrition and Metabolism. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-447427
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-447427