Glycolysis in the African Trypanosome : Targeting Enzymes and Their Subcellular Compartments for Therapeutic Development
Joint Authors
Coley, April F.
Morris, James C.
Morris, Meredith T.
Dodson, Heidi C.
Source
Molecular Biology International
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-04-11
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Subspecies of the African trypanosome, Trypanosoma brucei, which cause human African trypanosomiasis, are transmitted by the tsetse fly, with transmission-essential lifecycle stages occurring in both the insect vector and human host.
During infection of the human host, the parasite is limited to using glycolysis of host sugar for ATP production.
This dependence on glucose breakdown presents a series of targets for potential therapeutic development, many of which have been explored and validated as therapeutic targets experimentally.
These include enzymes directly involved in glucose metabolism (e.g., the trypanosome hexokinases), as well as cellular components required for development and maintenance of the essential subcellular compartments that house the major part of the pathway, the glycosomes.
American Psychological Association (APA)
Coley, April F.& Dodson, Heidi C.& Morris, Meredith T.& Morris, James C.. 2011. Glycolysis in the African Trypanosome : Targeting Enzymes and Their Subcellular Compartments for Therapeutic Development. Molecular Biology International،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-447438
Modern Language Association (MLA)
Coley, April F.…[et al.]. Glycolysis in the African Trypanosome : Targeting Enzymes and Their Subcellular Compartments for Therapeutic Development. Molecular Biology International No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-447438
American Medical Association (AMA)
Coley, April F.& Dodson, Heidi C.& Morris, Meredith T.& Morris, James C.. Glycolysis in the African Trypanosome : Targeting Enzymes and Their Subcellular Compartments for Therapeutic Development. Molecular Biology International. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-447438
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-447438