Genetic Associations in Acquired Immune-Mediated Bone Marrow Failure Syndromes : Insights in Aplastic Anemia and Chronic Idiopathic Neutropenia
Joint Authors
Papadaki, Helen A.
Mavroudi, Irene
Source
Clinical and Developmental Immunology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-08-26
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Increasing interest on the field of autoimmune diseases has unveiled a plethora of genetic factors that predispose to these diseases.
However, in immune-mediated bone marrow failure syndromes, such as acquired aplastic anemia and chronic idiopathic neutropenia, in which the pathophysiology results from a myelosuppressive bone marrow microenvironment mainly due to the presence of activated T lymphocytes, leading to the accelerated apoptotic death of the hematopoietic stem and progenitor cells, such genetic associations have been very limited.
Various alleles and haplotypes of human leucocyte antigen (HLA) molecules have been implicated in the predisposition of developing the above diseases, as well as polymorphisms of inhibitory cytokines such as interferon-γ, tumor necrosis factor-α, and transforming growth factor-β1 along with polymorphisms on molecules of the immune system including the T-bet transcription factor and signal transducers and activators of transcription.
In some cases, specific polymorphisms have been implicated in the outcome of treatment on those patients.
American Psychological Association (APA)
Mavroudi, Irene& Papadaki, Helen A.. 2012. Genetic Associations in Acquired Immune-Mediated Bone Marrow Failure Syndromes : Insights in Aplastic Anemia and Chronic Idiopathic Neutropenia. Clinical and Developmental Immunology،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-447450
Modern Language Association (MLA)
Mavroudi, Irene& Papadaki, Helen A.. Genetic Associations in Acquired Immune-Mediated Bone Marrow Failure Syndromes : Insights in Aplastic Anemia and Chronic Idiopathic Neutropenia. Clinical and Developmental Immunology No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-447450
American Medical Association (AMA)
Mavroudi, Irene& Papadaki, Helen A.. Genetic Associations in Acquired Immune-Mediated Bone Marrow Failure Syndromes : Insights in Aplastic Anemia and Chronic Idiopathic Neutropenia. Clinical and Developmental Immunology. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-447450
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-447450