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The Relationship between Renal Dysfunction and Abnormalities of the Immune System in Patients with Decompensated Cirrhosis
Joint Authors
Kondo, Yasuteru
Shimosegawa, Tooru
Kakazu, Eiji
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-26
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
In patients with advanced cirrhosis, not only hepatocellular carcinoma but also bacterial infections, such as spontaneous bacterial peritonitis (SBP) or pneumonia, are frequent clinical complications in such immune-compromised patients.
These pathologies often progress to renal dysfunction, especially hepatorenal syndrome (HRS).
The central pathology of HRS is splanchnic arterial vasodilation and hyperpermeability followed by bacterial translocation (BT).
BT induces a severe inflammatory response in the peritoneal lymphoid tissue, with the activation of the immune systems and the long-lasting production of vasoactive mediators that can impair the circulatory function and cause renal failure.
Recent studies report that the plasma amino acid imbalance appeared to be related to an abnormality of the immune system in patients with decompensated cirrhosis.
This paper can provide a new approach for future studies of the pathology in cirrhotic patients with renal dysfunction.
American Psychological Association (APA)
Kakazu, Eiji& Kondo, Yasuteru& Shimosegawa, Tooru. 2012. The Relationship between Renal Dysfunction and Abnormalities of the Immune System in Patients with Decompensated Cirrhosis. ISRN Gastroenterology،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-447454
Modern Language Association (MLA)
Kakazu, Eiji…[et al.]. The Relationship between Renal Dysfunction and Abnormalities of the Immune System in Patients with Decompensated Cirrhosis. ISRN Gastroenterology No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-447454
American Medical Association (AMA)
Kakazu, Eiji& Kondo, Yasuteru& Shimosegawa, Tooru. The Relationship between Renal Dysfunction and Abnormalities of the Immune System in Patients with Decompensated Cirrhosis. ISRN Gastroenterology. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-447454
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-447454