Towards Curative Cancer Immunotherapy : Overcoming Posttherapy Tumor Escape
Joint Authors
Source
Clinical and Developmental Immunology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-31
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The past decade has witnessed the evolvement of cancer immunotherapy as an increasingly effective therapeutic modality, evidenced by the approval of two immune-based products by the FDA, that is, the cancer vaccine Provenge (sipuleucel-T) for prostate cancer and the antagonist antibody against cytotoxic T-lymphocyte antigen-4 (CTLA-4) ipilimumab for advanced melanoma.
In addition, the clinical evaluations of a variety of promising immunotherapy drugs are well under way.
Benefiting from more efficacious immunotherapeutic agents and treatment strategies, a number of recent clinical studies have achieved unprecedented therapeutic outcomes in some patients with certain types of cancers.
Despite these advances, however, the efficacy of most cancer immunotherapies currently under clinical development has been modest.
A recurring scenario is that therapeutic maneuvers initially led to measurable antitumor immune responses in cancer patients but ultimately failed to improve patient outcomes.
It is increasingly recognized that tumor cells can antagonize therapy-induced immune attacks through a variety of counterregulation mechanisms, which represent a fundamental barrier to the success of cancer immunotherapy.
Herein we summarize the findings from some recent preclinical and clinical studies, focusing on how tumor cells advance their survival and expansion by hijacking therapy-induced immune effector mechanisms that would otherwise mediate their destruction.
American Psychological Association (APA)
Zhou, Gang& Levitsky, Hyam. 2012. Towards Curative Cancer Immunotherapy : Overcoming Posttherapy Tumor Escape. Clinical and Developmental Immunology،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-447481
Modern Language Association (MLA)
Zhou, Gang& Levitsky, Hyam. Towards Curative Cancer Immunotherapy : Overcoming Posttherapy Tumor Escape. Clinical and Developmental Immunology No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-447481
American Medical Association (AMA)
Zhou, Gang& Levitsky, Hyam. Towards Curative Cancer Immunotherapy : Overcoming Posttherapy Tumor Escape. Clinical and Developmental Immunology. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-447481
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-447481