Transforming Growth Factor-Beta Signaling in the Neural Stem Cell Niche : A Therapeutic Target for Huntington's Disease
Joint Authors
Kandasamy, Mahesh
Winkler, Jürgen
Aigner, Ludwig
Bogdahn, Ulrich
Reilmann, Ralf
Source
Neurology Research International
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-05-19
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
The neural stem cell niches possess the regenerative capacity to generate new functional neurons in the adult brain, suggesting the possibility of endogenous neuronal replacement after injury or disease.
Huntington disease (HD) is a neurodegenerative disease and characterized by neuronal loss in the basal ganglia, leading to motor, cognitive, and psychological disabilities.
Apparently, in order to make use of the neural stem cell niche as a therapeutic concept for repair strategies in HD, it is important to understand the cellular and molecular composition of the neural stem cell niche under such neurodegenerative conditions.
This paper mainly discusses the current knowledge on the regulation of the hippocampal neural stem cell niche in the adult brain and by which mechanism it might be compromised in the case of HD.
American Psychological Association (APA)
Kandasamy, Mahesh& Reilmann, Ralf& Winkler, Jürgen& Bogdahn, Ulrich& Aigner, Ludwig. 2011. Transforming Growth Factor-Beta Signaling in the Neural Stem Cell Niche : A Therapeutic Target for Huntington's Disease. Neurology Research International،Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-447488
Modern Language Association (MLA)
Kandasamy, Mahesh…[et al.]. Transforming Growth Factor-Beta Signaling in the Neural Stem Cell Niche : A Therapeutic Target for Huntington's Disease. Neurology Research International No. 2011 (2011), pp.1-13.
https://search.emarefa.net/detail/BIM-447488
American Medical Association (AMA)
Kandasamy, Mahesh& Reilmann, Ralf& Winkler, Jürgen& Bogdahn, Ulrich& Aigner, Ludwig. Transforming Growth Factor-Beta Signaling in the Neural Stem Cell Niche : A Therapeutic Target for Huntington's Disease. Neurology Research International. 2011. Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-447488
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-447488