Transforming Growth Factor-Beta Signaling in the Neural Stem Cell Niche : A Therapeutic Target for Huntington's Disease

Joint Authors

Kandasamy, Mahesh
Winkler, Jürgen
Aigner, Ludwig
Bogdahn, Ulrich
Reilmann, Ralf

Source

Neurology Research International

Issue

Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-13, 13 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2011-05-19

Country of Publication

Egypt

No. of Pages

13

Main Subjects

Medicine

Abstract EN

The neural stem cell niches possess the regenerative capacity to generate new functional neurons in the adult brain, suggesting the possibility of endogenous neuronal replacement after injury or disease.

Huntington disease (HD) is a neurodegenerative disease and characterized by neuronal loss in the basal ganglia, leading to motor, cognitive, and psychological disabilities.

Apparently, in order to make use of the neural stem cell niche as a therapeutic concept for repair strategies in HD, it is important to understand the cellular and molecular composition of the neural stem cell niche under such neurodegenerative conditions.

This paper mainly discusses the current knowledge on the regulation of the hippocampal neural stem cell niche in the adult brain and by which mechanism it might be compromised in the case of HD.

American Psychological Association (APA)

Kandasamy, Mahesh& Reilmann, Ralf& Winkler, Jürgen& Bogdahn, Ulrich& Aigner, Ludwig. 2011. Transforming Growth Factor-Beta Signaling in the Neural Stem Cell Niche : A Therapeutic Target for Huntington's Disease. Neurology Research International،Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-447488

Modern Language Association (MLA)

Kandasamy, Mahesh…[et al.]. Transforming Growth Factor-Beta Signaling in the Neural Stem Cell Niche : A Therapeutic Target for Huntington's Disease. Neurology Research International No. 2011 (2011), pp.1-13.
https://search.emarefa.net/detail/BIM-447488

American Medical Association (AMA)

Kandasamy, Mahesh& Reilmann, Ralf& Winkler, Jürgen& Bogdahn, Ulrich& Aigner, Ludwig. Transforming Growth Factor-Beta Signaling in the Neural Stem Cell Niche : A Therapeutic Target for Huntington's Disease. Neurology Research International. 2011. Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-447488

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-447488