Lung and Intestine : A Specific Link in an Ulcerative Colitis Rat Model
Joint Authors
Yang, Xue
Gao, Si-hua
Zhu, Li
Jing, Shan
Wang, Xin-Yue
Liu, Yuan
Source
Gastroenterology Research and Practice
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-28
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Background.
To investigate the link and mechanisms between intestine and lung in the ulcerative colitis (UC) rat model.
Materials and Methods.
We used the UC rat model by immunological sensitization combined with local 2, 4, 6-trinitrobenzene sulfonic acid (TNBS) in 50% ethanol enema, observed dynamically animal general state and body weight, examined the histological and functional changes in the colon, lung, liver, and kidney tissues, and detected microvascular endothelium response towards inflammation characterized with the expression of iNOS, TXB2, P-selectin, ICAM-1, and vascular endothelial growth factor A (VEGF-A) in the colon and lung tissue.
Results.
Pulmonary function results suggested ventilator disorder, and pathological findings showed interstitial pneumonia.
There were no significant changes in the liver and kidney function and histopathology.
The colon and lung tissue iNOS, TXB2, P-selectin, ICAM-1, and VEGF-A expression of the model rats was significantly higher than the normal rats at both time points.
Conclusions.
Our study is the first to demonstrate the close association between the large intestine and lung in the immune-TNBS-ethanol-induced UC rat model.
Different organs and tissues with the same embryonic origin may share the same pathological specificities in a disease.
The present study provided a new way of thinking for pathological changes in clinical complex diseases manifested with multiorgan damage.
American Psychological Association (APA)
Liu, Yuan& Wang, Xin-Yue& Yang, Xue& Jing, Shan& Zhu, Li& Gao, Si-hua. 2013. Lung and Intestine : A Specific Link in an Ulcerative Colitis Rat Model. Gastroenterology Research and Practice،Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-447503
Modern Language Association (MLA)
Liu, Yuan…[et al.]. Lung and Intestine : A Specific Link in an Ulcerative Colitis Rat Model. Gastroenterology Research and Practice No. 2013 (2013), pp.1-13.
https://search.emarefa.net/detail/BIM-447503
American Medical Association (AMA)
Liu, Yuan& Wang, Xin-Yue& Yang, Xue& Jing, Shan& Zhu, Li& Gao, Si-hua. Lung and Intestine : A Specific Link in an Ulcerative Colitis Rat Model. Gastroenterology Research and Practice. 2013. Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-447503
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-447503