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XRCC7 rs#7003908 Polymorphism and Helicobacter pylori Infection-Related Gastric Antrum Adenocarcinoma
Joint Authors
Wang, Chao
Long, Xi-Dai
Huang, Bing-Chen
Huang, Xiao-Ying
Huang, Cen-Han
Yao, Jin-Guang
Liao, Pinhu
Source
International Journal of Genomics
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-11
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
The X-ray repair cross-complementing group 7 (XRCC7) plays a key role in DNA repair that protects against genetic instability and carcinogenesis.
To determine whether XRCC7 rs#7003908 polymorphism (XRCC7P) is associated with Helicobacter pylori (H.
pylori) infection-related gastric antrum adenocarcinoma (GAA) risk, we conducted a hospital-based case-control study, including 642 patients with pathologically confirmed GAA and 927 individually matched controls without any evidence of tumours or precancerous lesions, among Guangxi population.
Increased risks of GAA were observed for individuals with cagA positive (odds ratio (OR) 6.38; 95% confidence interval (CI) 5.03–8.09).
We also found that these individuals with the genotypes of XRCC7 rs#7003908 G alleles (XRCC7-TG or -GG) featured increasing risk of GAA (ORs 2.80 and 5.13, resp.), compared with the homozygote of XRCC7 rs#7003908 T alleles (XRCC7-TT).
GAA risk, moreover, did appear to differ more significantly among individuals featuring cagA-positive status, whose adjusted ORs (95% CIs) were 15.74 (10.89–22.77) for XRCC7-TG and 38.49 (22.82–64.93) for XRCC7-GG, respectively.
Additionally, this polymorphism multiplicatively interacted with XRCC3 codon 241 polymorphism with respect to HCC risk (ORinteraction=1.49).
These results suggest that XRCC7P may be associated with the risk of Guangxiese GAA related to cagA.
American Psychological Association (APA)
Wang, Chao& Huang, Xiao-Ying& Yao, Jin-Guang& Huang, Bing-Chen& Huang, Cen-Han& Liao, Pinhu…[et al.]. 2013. XRCC7 rs#7003908 Polymorphism and Helicobacter pylori Infection-Related Gastric Antrum Adenocarcinoma. International Journal of Genomics،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-447513
Modern Language Association (MLA)
Wang, Chao…[et al.]. XRCC7 rs#7003908 Polymorphism and Helicobacter pylori Infection-Related Gastric Antrum Adenocarcinoma. International Journal of Genomics No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-447513
American Medical Association (AMA)
Wang, Chao& Huang, Xiao-Ying& Yao, Jin-Guang& Huang, Bing-Chen& Huang, Cen-Han& Liao, Pinhu…[et al.]. XRCC7 rs#7003908 Polymorphism and Helicobacter pylori Infection-Related Gastric Antrum Adenocarcinoma. International Journal of Genomics. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-447513
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-447513