RKIP Suppresses Breast Cancer Metastasis to the Bone by Regulating Stroma-Associated Genes
Joint Authors
Frankenberger, Casey A.
Bevilacqua, Elena
Rosner, Marsha Rich
Source
International Journal of Breast Cancer
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-12
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
In the past decade cancer research has recognized the importance of tumorstroma interactions for the progression of primary tumors to an aggressive and invasive phenotype and for colonization of new organs in the context of metastasis.
The dialogue between tumor cells and the surrounding stroma is a complex and dynamic phenomenon, as many cell types and soluble factors are involved.
While the function of many of the players involved in this cross talk have been studied, the regulatory mechanisms and signaling pathways that control their expression haven’t been investigated in depth.
By using a novel, interdisciplinary approach applied to the mechanism of action of the metastasis suppressor, Raf kinase inhibitory protein (RKIP), we identified a signaling pathway that suppresses invasion and metastasis through regulation of stroma-associated genes.
Conceptually, the approach we developed uses a master regulator and expression arrays from breast cancer patients to formulate hypotheses based on clinical data.
Experimental validation is followed by further bioinformatic analysis to establish the clinical significance of discoveries.
Using RKIP as an example we show here that this multi-step approach can be used to identify gene regulatory mechanisms that affect tumor-stroma interactions that in turn influence metastasis to the bone or other organs.
American Psychological Association (APA)
Bevilacqua, Elena& Frankenberger, Casey A.& Rosner, Marsha Rich. 2012. RKIP Suppresses Breast Cancer Metastasis to the Bone by Regulating Stroma-Associated Genes. International Journal of Breast Cancer،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-447522
Modern Language Association (MLA)
Bevilacqua, Elena…[et al.]. RKIP Suppresses Breast Cancer Metastasis to the Bone by Regulating Stroma-Associated Genes. International Journal of Breast Cancer No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-447522
American Medical Association (AMA)
Bevilacqua, Elena& Frankenberger, Casey A.& Rosner, Marsha Rich. RKIP Suppresses Breast Cancer Metastasis to the Bone by Regulating Stroma-Associated Genes. International Journal of Breast Cancer. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-447522
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-447522