Focus on Brain Angiotensin III and Aminopeptidase A in the Control of Hypertension
Joint Authors
Mizutani, Shigehiko
Harding, Joseph W.
Wright, John W.
Source
International Journal of Hypertension
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-26
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The classic renin-angiotensin system (RAS) was initially described as a hormone system designed to mediate cardiovascular and body water regulation.
The discovery of a brain RAS composed of the necessary functional components (angiotensinogen, peptidases, angiotensins, and specific receptor proteins) independent of the peripheral system significantly expanded the possible physiological and pharmacological functions of this system.
This paper first describes the enzymatic pathways resulting in active angiotensin ligands and their interaction with AT1, AT2, and mas receptor subtypes.
Recent evidence points to important contributions by brain angiotensin III (AngIII) and aminopeptidases A (APA) and N (APN) in sustaining hypertension.
Next, we discuss current approaches to the treatment of hypertension followed by novel strategies that focus on limiting the binding of AngII and AngIII to the AT1 receptor subtype by influencing the activity of APA and APN.
We conclude with thoughts concerning future treatment approaches to controlling hypertension and hypotension.
American Psychological Association (APA)
Wright, John W.& Mizutani, Shigehiko& Harding, Joseph W.. 2012. Focus on Brain Angiotensin III and Aminopeptidase A in the Control of Hypertension. International Journal of Hypertension،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-447529
Modern Language Association (MLA)
Wright, John W.…[et al.]. Focus on Brain Angiotensin III and Aminopeptidase A in the Control of Hypertension. International Journal of Hypertension No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-447529
American Medical Association (AMA)
Wright, John W.& Mizutani, Shigehiko& Harding, Joseph W.. Focus on Brain Angiotensin III and Aminopeptidase A in the Control of Hypertension. International Journal of Hypertension. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-447529
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-447529