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The Relationship between Tuberculosis and Influenza Death during the Influenza (H1N1) Pandemic from 1918-19
Joint Authors
Source
Computational and Mathematical Methods in Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-17
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The epidemiological mechanisms behind the W-shaped age-specific influenza mortality during the Spanish influenza (H1N1) pandemic 1918-19 have yet to be fully clarified.
The present study aimed to develop a formal hypothesis: tuberculosis (TB) was associated with the W-shaped influenza mortality from 1918-19.
Three pieces of epidemiological information were assessed: (i) the epidemic records containing the age-specific numbers of cases and deaths of influenza from 1918-19, (ii) an outbreak record of influenza in a Swiss TB sanatorium during the pandemic, and (iii) the age-dependent TB mortality over time in the early 20th century.
Analyzing the data (i), we found that the W-shaped pattern was not only seen in mortality but also in the age-specific case fatality ratio, suggesting the presence of underlying age-specific risk factor(s) of influenza death among young adults.
From the data (ii), TB was shown to be associated with influenza death (P=0.09), and there was no influenza death among non-TB controls.
The data (iii) were analyzed by employing the age-period-cohort model, revealing harvesting effect in the period function of TB mortality shortly after the 1918-19 pandemic.
These findings suggest that it is worthwhile to further explore the role of TB in characterizing the age-specific risk of influenza death.
American Psychological Association (APA)
Oei, Welling& Nishiura, Hiroshi. 2012. The Relationship between Tuberculosis and Influenza Death during the Influenza (H1N1) Pandemic from 1918-19. Computational and Mathematical Methods in Medicine،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-447541
Modern Language Association (MLA)
Oei, Welling& Nishiura, Hiroshi. The Relationship between Tuberculosis and Influenza Death during the Influenza (H1N1) Pandemic from 1918-19. Computational and Mathematical Methods in Medicine No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-447541
American Medical Association (AMA)
Oei, Welling& Nishiura, Hiroshi. The Relationship between Tuberculosis and Influenza Death during the Influenza (H1N1) Pandemic from 1918-19. Computational and Mathematical Methods in Medicine. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-447541
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-447541