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Stability Indicating HPLC Determination of Risperidone in Bulk Drug and Pharmaceutical Formulations
Joint Authors
Sheth, Navin R.
Dedania, Zarna R.
Patel, Bhavna
Patel, Jigar B.
Dedania, Ronak R.
Source
International Journal of Analytical Chemistry
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-10
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The objective of the current study was to develop a validated stability-indicating assay method (SIAM) for risperidone after subjecting it to forced decomposition under hydrolysis, oxidation, photolysis, and thermal stress conditions.
The liquid chromatographic separation was achieved isocratically on a symmetry C18 column (5 μm size, 250 mm × 4.6 mm i.d.) using a mobile phase containing methanol: acetonitrile (80 : 20, v/v) at a flow rate of 1 mL/min and UV detection at 280 nm.
Retention time of risperidone was found to be 3.35±0.01.
The method was linear over the concentration range of 10–60 μg/mL(r2=0.998) with a limit of detection and quantitation of 1.79 and 5.44 μg/mL, respectively.
The method has the requisite accuracy, specificity, sensitivity, and precision to assay risperidone in bulk form and pharmaceutical dosage forms.
Degradation products resulting from the stress studies did not interfere with the detection of Risperidone, and the assay is thus stability indicating.
American Psychological Association (APA)
Dedania, Zarna R.& Dedania, Ronak R.& Sheth, Navin R.& Patel, Jigar B.& Patel, Bhavna. 2011. Stability Indicating HPLC Determination of Risperidone in Bulk Drug and Pharmaceutical Formulations. International Journal of Analytical Chemistry،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-447551
Modern Language Association (MLA)
Dedania, Zarna R.…[et al.]. Stability Indicating HPLC Determination of Risperidone in Bulk Drug and Pharmaceutical Formulations. International Journal of Analytical Chemistry No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-447551
American Medical Association (AMA)
Dedania, Zarna R.& Dedania, Ronak R.& Sheth, Navin R.& Patel, Jigar B.& Patel, Bhavna. Stability Indicating HPLC Determination of Risperidone in Bulk Drug and Pharmaceutical Formulations. International Journal of Analytical Chemistry. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-447551
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-447551