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KE and EE Genotypes of ICAM-1 Gene K469E Polymorphism Is Associated with Severe Preeclampsia
Joint Authors
Naghavi, Anoosh
Mohammadoo-khorasani, Milad
Tabatabai, Ehsan
Salimi, Saeedeh
Farajian-Mashhadi, Farzaneh
Yaghmaei, Minoo
Mokhtari, Mojgan
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-30
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Background.
Preeclampsia (PE) is one of the most important complications of pregnancy that is associated with significant mortality and morbidity in mother and fetus.
Since the etiologic factors in its development are still unclear, we aimed to examine the intercellular adhesion molecule-1 (ICAM-1) gene K469E polymorphism in preeclamptic and control healthy women.
Materials and Methods.
Genetic polymorphism was analyzed in 192 PE and 186 healthy control women.
PCR-RFLP method was used to identify K469E polymorphism.
Results.
The frequency of KK, KE, and EE genotypes of ICAM-1 gene was not different between PE patients and healthy pregnant women.
Whereas, the frequency of KE and EE genotypes was significantly higher in severe PE than mild PE women and control group, and the risk of severe PE was 2.4-fold higher in subjects with KE genotype (OR, 2.4 [95% CI, 1 to 5.9]; P=0.03) and 3.3-fold higher in subjects with EE genotype (OR, 3.3 [95% CI, 1.2 to 9]; P=0.015) compared to individuals with KK genotype.
Conclusion.
We concluded that KE and EE genotypes of K469E polymorphism could increase risk of severe PE.
American Psychological Association (APA)
Tabatabai, Ehsan& Salimi, Saeedeh& Mohammadoo-khorasani, Milad& Yaghmaei, Minoo& Mokhtari, Mojgan& Farajian-Mashhadi, Farzaneh…[et al.]. 2014. KE and EE Genotypes of ICAM-1 Gene K469E Polymorphism Is Associated with Severe Preeclampsia. Disease Markers،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-447558
Modern Language Association (MLA)
Tabatabai, Ehsan…[et al.]. KE and EE Genotypes of ICAM-1 Gene K469E Polymorphism Is Associated with Severe Preeclampsia. Disease Markers No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-447558
American Medical Association (AMA)
Tabatabai, Ehsan& Salimi, Saeedeh& Mohammadoo-khorasani, Milad& Yaghmaei, Minoo& Mokhtari, Mojgan& Farajian-Mashhadi, Farzaneh…[et al.]. KE and EE Genotypes of ICAM-1 Gene K469E Polymorphism Is Associated with Severe Preeclampsia. Disease Markers. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-447558
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-447558