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Integrin-Mediated Cell-Matrix Interaction in Physiological and Pathological Blood Vessel Formation
Joint Authors
Niland, Stephan
Eble, Johannes A.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-25, 25 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-18
Country of Publication
Egypt
No. of Pages
25
Main Subjects
Abstract EN
Physiological as well as pathological blood vessel formation are fundamentally dependent on cell-matrix interaction.
Integrins, a family of major cell adhesion receptors, play a pivotal role in development, maintenance, and remodeling of the vasculature.
Cell migration, invasion, and remodeling of the extracellular matrix (ECM) are integrin-regulated processes, and the expression of certain integrins also correlates with tumor progression.
Recent advances in the understanding of how integrins are involved in the regulation of blood vessel formation and remodeling during tumor progression are highlighted.
The increasing knowledge of integrin function at the molecular level, together with the growing repertoire of integrin inhibitors which allow their selective pharmacological manipulation, makes integrins suited as potential diagnostic markers and therapeutic targets.
American Psychological Association (APA)
Niland, Stephan& Eble, Johannes A.. 2011. Integrin-Mediated Cell-Matrix Interaction in Physiological and Pathological Blood Vessel Formation. Journal of Oncology،Vol. 2012, no. 2012, pp.1-25.
https://search.emarefa.net/detail/BIM-447588
Modern Language Association (MLA)
Niland, Stephan& Eble, Johannes A.. Integrin-Mediated Cell-Matrix Interaction in Physiological and Pathological Blood Vessel Formation. Journal of Oncology No. 2012 (2012), pp.1-25.
https://search.emarefa.net/detail/BIM-447588
American Medical Association (AMA)
Niland, Stephan& Eble, Johannes A.. Integrin-Mediated Cell-Matrix Interaction in Physiological and Pathological Blood Vessel Formation. Journal of Oncology. 2011. Vol. 2012, no. 2012, pp.1-25.
https://search.emarefa.net/detail/BIM-447588
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-447588