Regulation of Adherens Junction Dynamics by Phosphorylation Switches
Joint Authors
Zaidel-Bar, Ronen
Bertocchi, Cristina
Vaman Rao, Megha
Source
Journal of Signal Transduction
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-12
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Adherens junctions connect the actin cytoskeleton of neighboring cells through transmembrane cadherin receptors and a network of adaptor proteins.
The interactions between these adaptors and cadherin as well as the activity of actin regulators localized to adherens junctions are tightly controlled to facilitate cell junction assembly or disassembly in response to changes in external or internal forces and/or signaling.
Phosphorylation of tyrosine, serine, or threonine residues acts as a switch on the majority of adherens junction proteins, turning “on” or “off” their interactions with other proteins and/or their enzymatic activity.
Here, we provide an overview of the kinases and phosphatases regulating phosphorylation of adherens junction proteins and bring examples of phosphorylation events leading to the assembly or disassembly of adherens junctions, highlighting the important role of phosphorylation switches in regulating their dynamics.
American Psychological Association (APA)
Bertocchi, Cristina& Vaman Rao, Megha& Zaidel-Bar, Ronen. 2012. Regulation of Adherens Junction Dynamics by Phosphorylation Switches. Journal of Signal Transduction،Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-447593
Modern Language Association (MLA)
Bertocchi, Cristina…[et al.]. Regulation of Adherens Junction Dynamics by Phosphorylation Switches. Journal of Signal Transduction No. 2012 (2012), pp.1-14.
https://search.emarefa.net/detail/BIM-447593
American Medical Association (AMA)
Bertocchi, Cristina& Vaman Rao, Megha& Zaidel-Bar, Ronen. Regulation of Adherens Junction Dynamics by Phosphorylation Switches. Journal of Signal Transduction. 2012. Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-447593
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-447593