![](/images/graphics-bg.png)
Nuclear Phosphatidylcholine and Sphingomyelin Metabolism of Thyroid Cells Changes during Stratospheric Balloon Flight
Joint Authors
Cataldi, Samuela
Albi, Elisabetta
Perrella, Giuseppina
Villani, Maristella
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-11-30
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Nuclear sphingomyelin and phosphatidylcholine metabolism is involved in the response to ultraviolet radiation treatment in different ways related to the physiological state of cells.
To evaluate the effects of low levels of radiation from the stratosphere on thyroid cells, proliferating and quiescent FRTL-5 cells were flown in a stratospheric balloon (BIRBA mission).
After recovery, the activity of neutral sphingomyelinase, phosphatidylcholine-specific phospholipase C, sphingomyelin synthase, and reverse sphingomyelin synthase was assayed in purified nuclei and the nuclei-free fraction.
In proliferating FRTL-5, space radiation stimulate nuclear neutral sphingomyelinase and reverse sphingomyelin synthase activity, whereas phosphatidylcholine-specific phospholipase C and sphingomyelin synthase were inhibited, thus inducing sphingomyelin degradation and phosphatidylcholine synthesis.
This effect was lower in quiescent cells.
The possible role of nuclear lipid metabolism in the thyroid damage induced by space radiations is discussed.
American Psychological Association (APA)
Albi, Elisabetta& Cataldi, Samuela& Villani, Maristella& Perrella, Giuseppina. 2009. Nuclear Phosphatidylcholine and Sphingomyelin Metabolism of Thyroid Cells Changes during Stratospheric Balloon Flight. Journal of Biomedicine and Biotechnology،Vol. 2009, no. 2009, pp.1-5.
https://search.emarefa.net/detail/BIM-447607
Modern Language Association (MLA)
Albi, Elisabetta…[et al.]. Nuclear Phosphatidylcholine and Sphingomyelin Metabolism of Thyroid Cells Changes during Stratospheric Balloon Flight. Journal of Biomedicine and Biotechnology No. 2009 (2009), pp.1-5.
https://search.emarefa.net/detail/BIM-447607
American Medical Association (AMA)
Albi, Elisabetta& Cataldi, Samuela& Villani, Maristella& Perrella, Giuseppina. Nuclear Phosphatidylcholine and Sphingomyelin Metabolism of Thyroid Cells Changes during Stratospheric Balloon Flight. Journal of Biomedicine and Biotechnology. 2009. Vol. 2009, no. 2009, pp.1-5.
https://search.emarefa.net/detail/BIM-447607
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-447607