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Hypoglycemic Activity and Antioxidative Stress of Extracts and Corymbiferin from Swertia bimaculata In Vitro and In Vivo
Joint Authors
Yue, Yuedong
Min, Qiuxia
Chen, Jiachun
Chen, Cuiping
Zhang, Yutang
Xiao, Zuoqi
Liu, Zhaoxia
Wang, Yonglong
Wan, Luosheng
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-24
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The present study was to investigate the anti-diabetic activities of Swertia bimaculata.
Based on the glucose consumption of S.
bimaculata extractsand different fractions (petroleum, dichloromethane, ethyl acetate, n-butanol and water extracts) in 3T3-L1 adipocyte assay, ethanol (ETH) and dichloromethane (DTH) extracts had the most effective potency.
Furthermore, ETH, DTH and corymbiferin (the most abundant component of DTH) were evaluated for anti-diabetic effects in high fat and sucrose fed combined with low dose streptozocin induced diabetic rats.
DTH and corymbiferin displayed remarkable anti-diabetic activities.
The fasting blood glucose levels were significantly decreased, while the serum insulin levels were obviously increased.
The oral glucose tolerance was also improved.
The lowed serum total cholesterol, low density lipoprotein (LDL) and triglyceride levels and increased ratio of HDL (high density lipoprotein)/LDL were observed.
The insulin sensitivity was improved on the basis of increased expressions of insulin-receptor substrate-2, phosphatidylinositol 3-kinase and Ser/Thr kinase AKT2.
And also DTH and corymbiferin improved antioxidant capacity and carbohydrate metabolism in diabetic rats, along with the improvement of histopathology of livers and pancreatic β cells.
Corymbiferin was one of active constituents, responsible for anti-diabetic properties.
Therefore, S.
bimaculata could be considered as an alternative agent against diabetes mellitus.
American Psychological Association (APA)
Liu, Zhaoxia& Wan, Luosheng& Yue, Yuedong& Xiao, Zuoqi& Zhang, Yutang& Wang, Yonglong…[et al.]. 2013. Hypoglycemic Activity and Antioxidative Stress of Extracts and Corymbiferin from Swertia bimaculata In Vitro and In Vivo. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-447608
Modern Language Association (MLA)
Liu, Zhaoxia…[et al.]. Hypoglycemic Activity and Antioxidative Stress of Extracts and Corymbiferin from Swertia bimaculata In Vitro and In Vivo. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-447608
American Medical Association (AMA)
Liu, Zhaoxia& Wan, Luosheng& Yue, Yuedong& Xiao, Zuoqi& Zhang, Yutang& Wang, Yonglong…[et al.]. Hypoglycemic Activity and Antioxidative Stress of Extracts and Corymbiferin from Swertia bimaculata In Vitro and In Vivo. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-447608
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-447608