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The Role of EGFR Inhibitors in the Treatment of Metastatic Anal Canal Carcinoma : A Case Series
Joint Authors
Kontny, Ewa
Saif, Muhammad Wasif
Syrigos, Kostas N.
Shahrokni, Armin
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-13
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Anal cancer patients who have exhibited disease progression after having received all approved drugs pose a major therapeutic challenge.
In addition to cytotoxic agents, novel targeted agents are being developed and have an established role in the treatment of many solid tumors, including colon cancer.
However, their role in anal cancer is yet to be determined.
Most anal malignancies are squamous cell carcinomas often strongly expressing epidermal growth factor receptors (EGFRs).
Targeting the latter seems to result in favorable changes in tumor growth.
We present three cases of refractory anal cancers, treated with EGFR inhibitors, after having received the recommended chemotherapy regimens.
We conclude that EGFR inhibitors may play a vital role in the treatment of anal cancer and we suggest that large trials are be conducted in order to clarify their efficacy and to improve therapeutic management.
American Psychological Association (APA)
Saif, Muhammad Wasif& Kontny, Ewa& Syrigos, Kostas N.& Shahrokni, Armin. 2011. The Role of EGFR Inhibitors in the Treatment of Metastatic Anal Canal Carcinoma : A Case Series. Journal of Oncology،Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-447616
Modern Language Association (MLA)
Saif, Muhammad Wasif…[et al.]. The Role of EGFR Inhibitors in the Treatment of Metastatic Anal Canal Carcinoma : A Case Series. Journal of Oncology No. 2011 (2011), pp.1-5.
https://search.emarefa.net/detail/BIM-447616
American Medical Association (AMA)
Saif, Muhammad Wasif& Kontny, Ewa& Syrigos, Kostas N.& Shahrokni, Armin. The Role of EGFR Inhibitors in the Treatment of Metastatic Anal Canal Carcinoma : A Case Series. Journal of Oncology. 2011. Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-447616
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-447616