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Serum Biomarkers Identification by Mass Spectrometry in High-Mortality Tumors
Joint Authors
Fischietti, Mariafausta
Gaggiano, Agata
Tessitore, Alessandra
Verzella, Daniela
Capece, Daria
Alesse, Edoardo
Zazzeroni, Francesca
Cicciarelli, Germana
Source
International Journal of Proteomics
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-01-15
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Topics
Abstract EN
Cancer affects millions of people worldwide.
Tumor mortality is substantially due to diagnosis at stages that are too late for therapies to be effective.
Advances in screening methods have improved the early diagnosis, prognosis, and survival for some cancers.
Several validated biomarkers are currently used to diagnose and monitor the progression of cancer, but none of them shows adequate specificity, sensitivity, and predictive value for population screening.
So, there is an urgent need to isolate novel sensitive, specific biomarkers to detect the disease early and improve prognosis, especially in high-mortality tumors.
Proteomic techniques are powerful tools to help in diagnosis and monitoring of treatment and progression of the disease.
During the last decade, mass spectrometry has assumed a key role in most of the proteomic analyses that are focused on identifying cancer biomarkers in human serum, making it possible to identify and characterize at the molecular level many proteins or peptides differentially expressed.
In this paper we summarize the results of mass spectrometry serum profiling and biomarker identification in high mortality tumors, such as ovarian, liver, lung, and pancreatic cancer.
American Psychological Association (APA)
Tessitore, Alessandra& Gaggiano, Agata& Cicciarelli, Germana& Verzella, Daniela& Capece, Daria& Fischietti, Mariafausta…[et al.]. 2013. Serum Biomarkers Identification by Mass Spectrometry in High-Mortality Tumors. International Journal of Proteomics،Vol. 2013, no. 2013, pp.1-15.
https://search.emarefa.net/detail/BIM-447651
Modern Language Association (MLA)
Tessitore, Alessandra…[et al.]. Serum Biomarkers Identification by Mass Spectrometry in High-Mortality Tumors. International Journal of Proteomics No. 2013 (2013), pp.1-15.
https://search.emarefa.net/detail/BIM-447651
American Medical Association (AMA)
Tessitore, Alessandra& Gaggiano, Agata& Cicciarelli, Germana& Verzella, Daniela& Capece, Daria& Fischietti, Mariafausta…[et al.]. Serum Biomarkers Identification by Mass Spectrometry in High-Mortality Tumors. International Journal of Proteomics. 2013. Vol. 2013, no. 2013, pp.1-15.
https://search.emarefa.net/detail/BIM-447651
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-447651