Enhancement of Oral Bioavailability of Puerarin by Polybutylcyanoacrylate Nanoparticles
Joint Authors
Zhai, Guangxi
Guo, Chenyu
Duan, Rui
Zhao, Lixia
Wang, Haigang
Zhang, Jing
Gu, Jinsong
Liu, Anchang
Wang, Shuang
Sun, Min
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-06
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Engineering Sciences and Information Technology
Chemistry
Civil Engineering
Abstract EN
The interest using novel drug delivery systems to improve oral bioavailability of drug with poor solubility is increasing.
In this study, a new oral delivery system, polybutylcyanoacrylate nanoparticles (PBCNs), was introduced to improve the oral bioavailability of puerarin (PUE).
PUE-loaded PBCN was successfully prepared by anionic polymerization method.
Characterization of PUE-loaded PBCN was evaluated with morphology, size, zeta potential, and in vitro release study.
The PBCN loading PUE exhibited a spherical shape under transmission electron microscopy with an average size of 159.4 nm, and the zeta potential was −15.0 mV.
The in vitro release of PUE-loaded PBCN showed an initial burst release followed by a sustained release.
Physicochemical state of PUE in PBCN was investigated by differential scanning colorimetry, X-ray diffraction, and Fourier transform infrared spectroscopy.
The results indicated that PUE in PBCN was in a noncrystalline state.
The oral pharmacokinetic study in rats showed that the relative bioavailability of PUE-encapsulated PBCN to the crude PUE was more than 550%.
It can be concluded that PBCN as an oral drug carrier can significantly improve the oral bioavailability of PUE.
American Psychological Association (APA)
Zhao, Lixia& Liu, Anchang& Sun, Min& Gu, Jinsong& Wang, Haigang& Wang, Shuang…[et al.]. 2011. Enhancement of Oral Bioavailability of Puerarin by Polybutylcyanoacrylate Nanoparticles. Journal of Nanomaterials،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-447718
Modern Language Association (MLA)
Zhao, Lixia…[et al.]. Enhancement of Oral Bioavailability of Puerarin by Polybutylcyanoacrylate Nanoparticles. Journal of Nanomaterials No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-447718
American Medical Association (AMA)
Zhao, Lixia& Liu, Anchang& Sun, Min& Gu, Jinsong& Wang, Haigang& Wang, Shuang…[et al.]. Enhancement of Oral Bioavailability of Puerarin by Polybutylcyanoacrylate Nanoparticles. Journal of Nanomaterials. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-447718
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-447718