Brown Fat Expresses Adiponectin in Humans

Joint Authors

Giorgio, De Toma
Zinnamosca, Laura
Serra, Valentina
Di Gioia, Cira
Ciardi, Antonio
Iacobellis, Gianluca
Chiappetta, Caterina
Marinelli, Cristiano
Claudio, Letizia
Petramala, Luigi

Source

International Journal of Endocrinology

Issue

Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2013-11-14

Country of Publication

Egypt

No. of Pages

6

Main Subjects

Biology

Abstract EN

The presence of brown adipose tissue (BAT) in humans is unclear.

Pheochromocytomas (PHEO) are rare tumors of neuroectodermal origin which occur in 0.1-0.2% of patients with hypertension.

We sought to evaluate the presence and activity of BAT surrounding adrenal PHEO in a well-studied sample of 11 patients who were diagnosed with PHEO and then underwent adrenalectomy.

Areas of white fat (WAT) and BAT surrounding PHEO were obtained by Laser Capture Microdissection for analysis of uncoupling protein (UCP)-1 and adiponectin mRNA expression.

Adiponectin and UCP-1 mRNA levels were significantly higher in BAT than in WAT (0.62 versus 0.15 and 362.4 versus 22.1, resp., P<0.01 for both).

Adiponectin mRNA levels significantly correlated with urinary metanephrines (r=0.76, P<0.01), vanilly mandelic acid (VMA) (r=0.95, P<0.01), and serum adiponectin levels (r=0.95, P<0.01).

Serum adiponectin levels significantly decreased (24.2±2 μg/mL versus 18±11 μg/mL, P<0.01) after adrenalectomy in PHEO subjects.

This study provides the following findings: (1) BAT surrounding PHEO expresses adiponectin and UCP-1 mRNA, (2) expression of adiponectin mRNA is significantly higher in BAT than in WAT surrounding PHEO, and (3) catecholamines and serum adiponectin levels significantly correlate with BAT UCP-1 and adiponectin mRNA.

American Psychological Association (APA)

Iacobellis, Gianluca& Di Gioia, Cira& Petramala, Luigi& Chiappetta, Caterina& Serra, Valentina& Zinnamosca, Laura…[et al.]. 2013. Brown Fat Expresses Adiponectin in Humans. International Journal of Endocrinology،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-447727

Modern Language Association (MLA)

Iacobellis, Gianluca…[et al.]. Brown Fat Expresses Adiponectin in Humans. International Journal of Endocrinology No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-447727

American Medical Association (AMA)

Iacobellis, Gianluca& Di Gioia, Cira& Petramala, Luigi& Chiappetta, Caterina& Serra, Valentina& Zinnamosca, Laura…[et al.]. Brown Fat Expresses Adiponectin in Humans. International Journal of Endocrinology. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-447727

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-447727