Enhanced Growth Inhibition of Osteosarcoma by Cytotoxic Polymerized Liposomal Nanoparticles Targeting the Alcam Cell Surface Receptor
Joint Authors
Nagy, Jon O.
Kang, HyungGyoo
Marks, James D.
Chan, Jason
McCabe, Katelyn E.
Liu, Bin
Landaw, Elliot M.
Federman, Noah
Denny, Christopher T.
Triche, Timothy
Wu, Anna M.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-09-11
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Osteosarcoma is the most common primary malignancy of bone in children, adolescents, and adults.
Despite extensive surgery and adjuvant aggressive high-dose systemic chemotherapy with potentially severe bystander side effects, cure is attainable in about 70% of patients with localized disease and only 20%–30% of those patients with metastatic disease.
Targeted therapies clearly are warranted in improving our treatment of this adolescent killer.
However, a lack of osteosarcoma-associated/specific markers has hindered development of targeted therapeutics.
We describe a novel osteosarcoma-associated cell surface antigen, ALCAM.
We, then, create an engineered anti-ALCAM-hybrid polymerized liposomal nanoparticle immunoconjugate (α-AL-HPLN) to specifically target osteosarcoma cells and deliver a cytotoxic chemotherapeutic agent, doxorubicin.
We have demonstrated that α-AL-HPLNs have significantly enhanced cytotoxicity over untargeted HPLNs and over a conventional liposomal doxorubicin formulation.
In this way, α-AL-HPLNs are a promising new strategy to specifically deliver cytotoxic agents in osteosarcoma.
American Psychological Association (APA)
Federman, Noah& Chan, Jason& Nagy, Jon O.& Landaw, Elliot M.& McCabe, Katelyn E.& Wu, Anna M.…[et al.]. 2012. Enhanced Growth Inhibition of Osteosarcoma by Cytotoxic Polymerized Liposomal Nanoparticles Targeting the Alcam Cell Surface Receptor. Sarcoma،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-447740
Modern Language Association (MLA)
Federman, Noah…[et al.]. Enhanced Growth Inhibition of Osteosarcoma by Cytotoxic Polymerized Liposomal Nanoparticles Targeting the Alcam Cell Surface Receptor. Sarcoma No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-447740
American Medical Association (AMA)
Federman, Noah& Chan, Jason& Nagy, Jon O.& Landaw, Elliot M.& McCabe, Katelyn E.& Wu, Anna M.…[et al.]. Enhanced Growth Inhibition of Osteosarcoma by Cytotoxic Polymerized Liposomal Nanoparticles Targeting the Alcam Cell Surface Receptor. Sarcoma. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-447740
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-447740