Characterization of a Novel Polymorphism in PPARG Regulatory Region Associated with Type 2 Diabetes and Diabetic Retinopathy in Italy
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-12-25
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Peroxisome proliferator-activated receptor gamma polymorphisms have been widely associated with type 2 diabetes, although their role in the pathogenesis of vascular complications is not yet demonstrated.
In this study, a cohort of 211 type 2 diabetes, 205 obese, and 254 control individuals was genotyped for Pro12Ala, C1431T, C-2821T polymorphisms, and for a newly identified polymorphism (A-2819G).
The above-mentioned polymorphisms were analyzed by gene-specific PCR and direct sequencing of all samples.
A significant difference was found for -2819G frequency when patients with type 2 diabetes—particularly diabetic women with the proliferative retinopathy—were compared with healthy control individuals.
In conclusion, we identified a novel polymorphism, A-2819G, in PPARG gene, and we found it to be associated with type 2 diabetes and proliferative retinopathy in diabetic females.
In the analyzed population, this variant represents a genetic risk factor for developing the diabetic retinopathy, whereas Pro12Ala and C1431T do not.
American Psychological Association (APA)
2008. Characterization of a Novel Polymorphism in PPARG Regulatory Region Associated with Type 2 Diabetes and Diabetic Retinopathy in Italy. Journal of Biomedicine and Biotechnology،Vol. 2009, no. 2009, pp.1-7.
https://search.emarefa.net/detail/BIM-447743
Modern Language Association (MLA)
Characterization of a Novel Polymorphism in PPARG Regulatory Region Associated with Type 2 Diabetes and Diabetic Retinopathy in Italy. Journal of Biomedicine and Biotechnology No. 2009 (2009), pp.1-7.
https://search.emarefa.net/detail/BIM-447743
American Medical Association (AMA)
Characterization of a Novel Polymorphism in PPARG Regulatory Region Associated with Type 2 Diabetes and Diabetic Retinopathy in Italy. Journal of Biomedicine and Biotechnology. 2008. Vol. 2009, no. 2009, pp.1-7.
https://search.emarefa.net/detail/BIM-447743
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-447743