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Jejunal Cancer with WRN Mutation Identified from Next-Generation Sequencing : A Case Study and Minireview
Joint Authors
Chu, Jan-Show
Shiah, Her-Shyong
Hsu, Nan-Yung
Huang, Hsiu-Ying
Yen, Yun
Chang, Christopher
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-15
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Small bowel cancer is a rare, gastrointestinal cancer originating from the small intestines.
Carcinogenesis in the jejunum, the middle segment of the small intestines, occurs less commonly than in the duodenum and ileum.
Despite the increasing incidences globally, the cancer is still poorly understood, which includes lack of pathological understanding and etiological reasoning, as it seems to exhibit both similarities and differences with other types of cancers.
A 76-year-old Asian man was presented with abdominal pain, which was later attributed to an adenocarcinoma in the jejunum.
Initial immunoreactive staining results found no connections to colorectal cancer.
The microsatellite instability test was further examined by immunohistochemistry which revealed them to be wild-type.
From our exome-capture sequencing results, mutations of WRN may be important as they represent the only genetic defect in this jejunal cancer.
The patient has since undergone surgical resection of his cancer and is currently being treated with chemotherapy.
The pathology, genomic markers, and treatments are described along with literature review.
American Psychological Association (APA)
Chang, Christopher& Shiah, Her-Shyong& Hsu, Nan-Yung& Huang, Hsiu-Ying& Chu, Jan-Show& Yen, Yun. 2014. Jejunal Cancer with WRN Mutation Identified from Next-Generation Sequencing : A Case Study and Minireview. Case Reports in Surgery،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-447744
Modern Language Association (MLA)
Chang, Christopher…[et al.]. Jejunal Cancer with WRN Mutation Identified from Next-Generation Sequencing : A Case Study and Minireview. Case Reports in Surgery No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-447744
American Medical Association (AMA)
Chang, Christopher& Shiah, Her-Shyong& Hsu, Nan-Yung& Huang, Hsiu-Ying& Chu, Jan-Show& Yen, Yun. Jejunal Cancer with WRN Mutation Identified from Next-Generation Sequencing : A Case Study and Minireview. Case Reports in Surgery. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-447744
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-447744