Evaluation of Anti-Candida Activity of Vitis vinifera L. Seed Extracts Obtained from Wine and Table Cultivars
Joint Authors
Gabrielli, Elena
D'Auria, Felicia Diodata
Vecchiarelli, Anna
Pericolini, Eva
Pasqua, Gabriella
Mulinacci, Nadia
Panella, Simona
Santamaria, Anna Rita
Innocenti, Marzia
Antonacci, Donato
Palamara, Anna Teresa
Simonetti, Giovanna
Cecchini, Francesca
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-23
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
For the first time, grape seed extracts (GSEs), obtained from wine and table cultivars of Vitis vinifera L., cultured in experimental fields of Lazio and Puglia regions of Italy and grown in different agronomic conditions, have been tested on 43 Candida species strains.
We demonstrated a significant correlation between the content of the flavan-3-ols in GSEs extracts, with a polymerization degree ≥4, and anti-Candida activity.
Moreover, we demonstrated that GSEs, obtained from plants cultured with reduced irrigation, showed a content of polymeric flavan-3-ols >250 mg/g with geometric mean MIC values between 5.7 and 20.2 mg/L against Candida albicans reference strains.
GSE, showing 573 mg/g of polymeric flavan-3-ols, has been tested in an experimental murine model of vaginal candidiasis by using noninvasive in vivo imaging technique.
The results pointed out a significant inhibition of Candida albicans load 5 days after challenge.
These findings indicate that GSEs with high content of polymeric flavan-3-ols can be used in mucosal infection as vaginal candidiasis.
American Psychological Association (APA)
Simonetti, Giovanna& Santamaria, Anna Rita& D'Auria, Felicia Diodata& Mulinacci, Nadia& Innocenti, Marzia& Cecchini, Francesca…[et al.]. 2014. Evaluation of Anti-Candida Activity of Vitis vinifera L. Seed Extracts Obtained from Wine and Table Cultivars. BioMed Research International،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-447751
Modern Language Association (MLA)
Simonetti, Giovanna…[et al.]. Evaluation of Anti-Candida Activity of Vitis vinifera L. Seed Extracts Obtained from Wine and Table Cultivars. BioMed Research International No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-447751
American Medical Association (AMA)
Simonetti, Giovanna& Santamaria, Anna Rita& D'Auria, Felicia Diodata& Mulinacci, Nadia& Innocenti, Marzia& Cecchini, Francesca…[et al.]. Evaluation of Anti-Candida Activity of Vitis vinifera L. Seed Extracts Obtained from Wine and Table Cultivars. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-447751
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-447751