Flavonoids Induce the Synthesis and Secretion of Neurotrophic Factors in Cultured Rat Astrocytes : A Signaling Response Mediated by Estrogen Receptor
Joint Authors
Choi, Roy Chi-Yan
Zhu, Kevin Yue
Bi, Cathy W. C.
Miernisha, Abudureyimu
Dong, Tina Ting-Xia
Tsim, Karl Wah-Keung
Xu, Sherry Li
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-25
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Neurotrophic factors are playing vital roles in survival, growth, and function of neurons.
Regulation of neurotrophic factors in the brain has been considered as one of the targets in developing drug or therapy against neuronal disorders.
Flavonoids, a family of multifunctional natural compounds, are well known for their neuronal beneficial effects.
Here, the effects of flavonoids on regulating neurotrophic factors were analyzed in cultured rat astrocytes.
Astrocyte is a major secreting source of neurotrophic factors in the brain.
Thirty-three flavonoids were screened in the cultures, and calycosin, isorhamnetin, luteolin, and genistein were identified to be highly active in inducing the synthesis and secretion of neurotrophic factors, including nerve growth factor (NGF), glial-derived neurotrophic factor (GDNF), and brain-derived neurotrophic factor (BDNF).
The inductions were in time- and dose-dependent manners.
In cultured astrocytes, the phosphorylation of estrogen receptor was triggered by application of flavonoids.
The phosphorylation was blocked by an inhibitor of estrogen receptor, which in parallel reduced the flavonoid-induced expression of neurotrophic factors.
The results proposed the role of flavonoids in protecting brain diseases, and therefore these flavonoids could be developed for health food supplement for patients suffering from neurodegenerative diseases.
American Psychological Association (APA)
Xu, Sherry Li& Bi, Cathy W. C.& Choi, Roy Chi-Yan& Zhu, Kevin Yue& Miernisha, Abudureyimu& Dong, Tina Ting-Xia…[et al.]. 2013. Flavonoids Induce the Synthesis and Secretion of Neurotrophic Factors in Cultured Rat Astrocytes : A Signaling Response Mediated by Estrogen Receptor. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-447758
Modern Language Association (MLA)
Xu, Sherry Li…[et al.]. Flavonoids Induce the Synthesis and Secretion of Neurotrophic Factors in Cultured Rat Astrocytes : A Signaling Response Mediated by Estrogen Receptor. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-447758
American Medical Association (AMA)
Xu, Sherry Li& Bi, Cathy W. C.& Choi, Roy Chi-Yan& Zhu, Kevin Yue& Miernisha, Abudureyimu& Dong, Tina Ting-Xia…[et al.]. Flavonoids Induce the Synthesis and Secretion of Neurotrophic Factors in Cultured Rat Astrocytes : A Signaling Response Mediated by Estrogen Receptor. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-447758
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-447758