Inhibitory Action of Quercetin on Eosinophil Activation In Vitro
Joint Authors
Asano, Kazuhito
Sakai-Kashiwabara, Misako
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-06
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The influence of quercetin on eosinophil functions was examined in vitro and in vivo.
The first set of experiments was undertaken to examine whether quercetin could suppress eosinophilia and IgE hyperproduction induced by Mesocestoides corti infection in BALB/c mice.
The number of peripheral blood eosinophils and IgE levels were examined 21 days after infection.
Oral administration of quercetin for 21 days could not suppress both peripheral blood eosinophilia and IgE hyperproduction, even when 20.0 mg/kg quercetin was used for treatment.
The second part of the experiment was designed to examine the influence of quercetin on eosinophil activation induced by SCF stimulation in vitro.
Eosinophils were obtained from M.
corti-infected mice and stimulated with SCF in the presence of various concentrations of quercetin for 24 h.
The addition of quercetin into cell cultures could suppress eosinophil activation induced by SCF stimulation as assessed by measuring the contents of RANTES, MIP-1β, ECP, and MBP in culture supernatants.
The minimum concentration of quercetin which caused significant suppression of factor secretion was 5.0 μM.
These results may suggest that quercetin will be a good candidate for the supplement on the management of eosinophil-mediated diseases, such as allergic rhinitis and asthma.
American Psychological Association (APA)
Sakai-Kashiwabara, Misako& Asano, Kazuhito. 2013. Inhibitory Action of Quercetin on Eosinophil Activation In Vitro. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-447761
Modern Language Association (MLA)
Sakai-Kashiwabara, Misako& Asano, Kazuhito. Inhibitory Action of Quercetin on Eosinophil Activation In Vitro. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-447761
American Medical Association (AMA)
Sakai-Kashiwabara, Misako& Asano, Kazuhito. Inhibitory Action of Quercetin on Eosinophil Activation In Vitro. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-447761
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-447761