Multivariate Granger Causality Analysis of Acupuncture Effects in Mild Cognitive Impairment Patients : An fMRI Study
Joint Authors
Shi, Xuemin
Chen, Xinghua
Xu, Maosheng
Chen, Shangjie
Bai, Lijun
Wang, Fang
Yin, Liang
Peng, Xuming
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-08-19
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Evidence from clinical reports has indicated that acupuncture has a promising effect on mild cognitive impairment (MCI).
However, it is still unknown that by what way acupuncture can modulate brain networks involving the MCI.
In the current study, multivariate Granger causality analysis (mGCA) was adopted to compare the interregional effective connectivity of brain networks by varying needling depths (deep acupuncture, DA; superficial acupuncture, SA) and at different cognitive states, which were the MCI and healthy control (HC).
Results from DA at KI3 in MCI showed that the dorsolateral prefrontal cortex and hippocampus emerged as central hubs and had significant causal influences with each other, but significant in HC for DA.
Moreover, only several brain regions had remarkable causal interactions following SA in MCI and even few brain regions following SA in HC.
Our results indicated that acupuncture at KI3 at different cognitive states and with varying needling depths may induce distinct reorganizations of effective connectivities of brain networks, and DA at KI3 in MCI can induce the strongest and more extensive effective connectivities related to the therapeutic effect of acupuncture in MCI.
The study demonstrated the relatively functional specificity of acupuncture at KI3 in MCI, and needling depths play an important role in acupuncture treatments.
American Psychological Association (APA)
Chen, Shangjie& Bai, Lijun& Xu, Maosheng& Wang, Fang& Yin, Liang& Peng, Xuming…[et al.]. 2013. Multivariate Granger Causality Analysis of Acupuncture Effects in Mild Cognitive Impairment Patients : An fMRI Study. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-447783
Modern Language Association (MLA)
Chen, Shangjie…[et al.]. Multivariate Granger Causality Analysis of Acupuncture Effects in Mild Cognitive Impairment Patients : An fMRI Study. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-447783
American Medical Association (AMA)
Chen, Shangjie& Bai, Lijun& Xu, Maosheng& Wang, Fang& Yin, Liang& Peng, Xuming…[et al.]. Multivariate Granger Causality Analysis of Acupuncture Effects in Mild Cognitive Impairment Patients : An fMRI Study. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-447783
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-447783