![](/images/graphics-bg.png)
Sarcopenia and Age-Related Endocrine Function
Joint Authors
Yamaguchi, Akihiko
Sakuma, Kunihiro
Source
International Journal of Endocrinology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-28
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Sarcopenia, the age-related loss of skeletal muscle, is characterized by a deterioration of muscle quantity and quality leading to a gradual slowing of movement, a decline in strength and power, and an increased risk of fall-related injuries.
Since sarcopenia is largely attributed to various molecular mediators affecting fiber size, mitochondrial homeostasis, and apoptosis, numerous targets exist for drug discovery.
In this paper, we summarize the current understanding of the endocrine contribution to sarcopenia and provide an update on hormonal intervention to try to improve endocrine defects.
Myostatin inhibition seems to be the most interesting strategy for attenuating sarcopenia other than resistance training with amino acid supplementation.
Testosterone supplementation in large amounts and at low frequency improves muscle defects with aging but has several side effects.
Although IGF-I is a potent regulator of muscle mass, its therapeutic use has not had a positive effect probably due to local IGF-I resistance.
Treatment with ghrelin may ameliorate the muscle atrophy elicited by age-dependent decreases in growth hormone.
Ghrelin is an interesting candidate because it is orally active, avoiding the need for injections.
A more comprehensive knowledge of vitamin-D-related mechanisms is needed to utilize this nutrient to prevent sarcopenia.
American Psychological Association (APA)
Sakuma, Kunihiro& Yamaguchi, Akihiko. 2012. Sarcopenia and Age-Related Endocrine Function. International Journal of Endocrinology،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-447792
Modern Language Association (MLA)
Sakuma, Kunihiro& Yamaguchi, Akihiko. Sarcopenia and Age-Related Endocrine Function. International Journal of Endocrinology No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-447792
American Medical Association (AMA)
Sakuma, Kunihiro& Yamaguchi, Akihiko. Sarcopenia and Age-Related Endocrine Function. International Journal of Endocrinology. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-447792
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-447792