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Lumbar Facet Joint Compressive Injury Induces Lasting Changes in Local Structure, Nociceptive Scores, and Inflammatory Mediators in a Novel Rat Model
Joint Authors
Yashpal, Kiran
Im, Hee-Jeong
Henry, James L.
Kim, Jaesung
Vernon, Howard
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-28
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Objective.
To develop a novel animal model of persisting lumbar facet joint pain.
Methods.
Sprague Dawley rats were anaesthetized and the right lumbar (L5/L6) facet joint was exposed and compressed to ~1 mm with modified clamps applied for three minutes; sham-operated and naïve animals were used as control groups.
After five days, animals were tested for hind-paw sensitivity using von Frey filaments and axial deep tissue sensitivity by algometer on assigned days up to 28 days.
Animals were sacrificed at selected times for histological and biochemical analysis.
Results.
Histological sections revealed site-specific loss of cartilage in model animals only.
Tactile hypersensitivity was observed for the ipsi- and contralateral paws lasting 28 days.
The threshold at which deep tissue pressure just elicited vocalization was obtained at three lumbar levels; sensitivity at L1>L3/4>L6.
Biochemical analyses revealed increases in proinflammatory cytokines, especially TNF-α, IL-1α, and IL-1β.
Conclusions.
These data suggest that compression of a facet joint induces a novel model of local cartilage loss accompanied by increased sensitivity to mechanical stimuli and by increases in inflammatory mediators.
This new model may be useful for studies on mechanisms and treatment of lumbar facet joint pain and osteoarthritis.
American Psychological Association (APA)
Henry, James L.& Yashpal, Kiran& Vernon, Howard& Kim, Jaesung& Im, Hee-Jeong. 2012. Lumbar Facet Joint Compressive Injury Induces Lasting Changes in Local Structure, Nociceptive Scores, and Inflammatory Mediators in a Novel Rat Model. Pain Research and Treatment،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-447826
Modern Language Association (MLA)
Henry, James L.…[et al.]. Lumbar Facet Joint Compressive Injury Induces Lasting Changes in Local Structure, Nociceptive Scores, and Inflammatory Mediators in a Novel Rat Model. Pain Research and Treatment No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-447826
American Medical Association (AMA)
Henry, James L.& Yashpal, Kiran& Vernon, Howard& Kim, Jaesung& Im, Hee-Jeong. Lumbar Facet Joint Compressive Injury Induces Lasting Changes in Local Structure, Nociceptive Scores, and Inflammatory Mediators in a Novel Rat Model. Pain Research and Treatment. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-447826
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-447826