Antiatherosclerotic Potential of Active Principle Isolated from Eugenia jambolana in Streptozotocin-Induced Diabetic Rats
Joint Authors
Prabhu, Krishna Madhava
Sharma, Suman Bala
Singh, Usha Rani
Tanwar, Reenu Singh
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-04-07
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The aim of the present study was to investigate the antiatherosclerotic effect of active principle (FIIc) isolated from aqueous fruit pulp extract of Eugenia jambolana.
Crude aqueous extract of E.
jambolana was subjected to purification using chromatographic techniques which yielded purified active compound (FIIc).
Purity of FIIc was tested by HPLC.
Phytochemical investigation of FIIc by NMR, IR, and UV spectra showed that the purified compound is α-hydroxy succinamic acid.
The streptozotocin- (STZ-) induced diabetic rats were fed atherosclerotic (Ath) diet containing 1.5 mL olive oil containing 8 mg (3, 20,000 IU) vitamin D2 and 40 mg cholesterol for 5 consecutive days.
The STZ-induced diabetic rats receiving Ath diet were orally administered FIIc at doses of 10, 15, and 20 mg/kg, and results were compared with reference drug, that is, glibenclamide (600 μg/mg) and healthy control.
30-day treatment with FIIc resulted in significant (P<.001) improvement in blood glucose, serum lipid profile, apolipoproteins (Apo A1 and apoB100), and endothelial dysfunction parameters.
Histomorphological studies also confirmed biochemical findings.
Our results showed that FIIc has protective effect on hyperglycemia-induced atherosclerosis.
American Psychological Association (APA)
Tanwar, Reenu Singh& Sharma, Suman Bala& Singh, Usha Rani& Prabhu, Krishna Madhava. 2011. Antiatherosclerotic Potential of Active Principle Isolated from Eugenia jambolana in Streptozotocin-Induced Diabetic Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-447828
Modern Language Association (MLA)
Tanwar, Reenu Singh…[et al.]. Antiatherosclerotic Potential of Active Principle Isolated from Eugenia jambolana in Streptozotocin-Induced Diabetic Rats. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-447828
American Medical Association (AMA)
Tanwar, Reenu Singh& Sharma, Suman Bala& Singh, Usha Rani& Prabhu, Krishna Madhava. Antiatherosclerotic Potential of Active Principle Isolated from Eugenia jambolana in Streptozotocin-Induced Diabetic Rats. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-447828
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-447828