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Novel Insights into the Vasoprotective Role of Heme Oxygenase-1
Joint Authors
Dovizio, Melania
Bruno, Annalisa
Di Francesco, Luigia
Marcantoni, Emanuela
Patrignani, Paola
Source
International Journal of Hypertension
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-22
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Cardiovascular risk factors contribute to enhanced oxidative stress which leads to endothelial dysfunction.
These events trigger platelet activation and their interaction with leukocytes and endothelial cells, thus contributing to the induction of chronic inflammatory processes at the vascular wall and to the development of atherosclerotic lesions and atherothrombosis.
In this scenario, endogenous antioxidant pathways are induced to restrain the development of vascular disease.
In the present paper, we will discuss the role of heme oxygenase (HO)-1 which is an enzyme of the heme catabolism and cleaves heme to form biliverdin and carbon monoxide (CO).
Biliverdin is reduced enzymatically to the potent antioxidant bilirubin.
Recent evidence supports the involvement of HO-1 in the antioxidant and antiinflammatory effect of cyclooxygenase(COX)-2-dependent prostacyclin in the vasculature.
Moreover, the role of HO-1 in estrogen vasoprotection is emerging.
Finally, possible strategies to develop novel therapeutics against cardiovascular disease by targeting the induction of HO-1 will be discussed.
American Psychological Association (APA)
Marcantoni, Emanuela& Di Francesco, Luigia& Dovizio, Melania& Bruno, Annalisa& Patrignani, Paola. 2012. Novel Insights into the Vasoprotective Role of Heme Oxygenase-1. International Journal of Hypertension،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-447846
Modern Language Association (MLA)
Marcantoni, Emanuela…[et al.]. Novel Insights into the Vasoprotective Role of Heme Oxygenase-1. International Journal of Hypertension No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-447846
American Medical Association (AMA)
Marcantoni, Emanuela& Di Francesco, Luigia& Dovizio, Melania& Bruno, Annalisa& Patrignani, Paola. Novel Insights into the Vasoprotective Role of Heme Oxygenase-1. International Journal of Hypertension. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-447846
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-447846