Aβ Internalization by Neurons and Glia
Joint Authors
Mohamed, Amany
Posse de Chaves, Elena
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-02-15
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
In the brain, the amyloid β peptide (Aβ) exists extracellularly and inside neurons.
The intracellular accumulation of Aβ in Alzheimer's disease brain has been questioned for a long time.
However, there is now sufficient strong evidence indicating that accumulation of Aβ inside neurons plays an important role in the pathogenesis of Alzheimer's disease.
Intraneuronal Aβ originates from intracellular cleavage of APP and from Aβ internalization from the extracellular milieu.
We discuss here the different molecular mechanisms that are responsible for Aβ internalization in neurons and the links between Aβ internalization and neuronal dysfunction and death.
A brief description of Aβ uptake by glia is also presented.
American Psychological Association (APA)
Mohamed, Amany& Posse de Chaves, Elena. 2011. Aβ Internalization by Neurons and Glia. International Journal of Alzheimer's Disease،Vol. 2011, no. 2011, pp.1-17.
https://search.emarefa.net/detail/BIM-447851
Modern Language Association (MLA)
Mohamed, Amany& Posse de Chaves, Elena. Aβ Internalization by Neurons and Glia. International Journal of Alzheimer's Disease No. 2011 (2011), pp.1-17.
https://search.emarefa.net/detail/BIM-447851
American Medical Association (AMA)
Mohamed, Amany& Posse de Chaves, Elena. Aβ Internalization by Neurons and Glia. International Journal of Alzheimer's Disease. 2011. Vol. 2011, no. 2011, pp.1-17.
https://search.emarefa.net/detail/BIM-447851
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-447851