Aβ Internalization by Neurons and Glia

Joint Authors

Mohamed, Amany
Posse de Chaves, Elena

Source

International Journal of Alzheimer's Disease

Issue

Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-17, 17 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2011-02-15

Country of Publication

Egypt

No. of Pages

17

Main Subjects

Diseases
Medicine

Abstract EN

In the brain, the amyloid β peptide (Aβ) exists extracellularly and inside neurons.

The intracellular accumulation of Aβ in Alzheimer's disease brain has been questioned for a long time.

However, there is now sufficient strong evidence indicating that accumulation of Aβ inside neurons plays an important role in the pathogenesis of Alzheimer's disease.

Intraneuronal Aβ originates from intracellular cleavage of APP and from Aβ internalization from the extracellular milieu.

We discuss here the different molecular mechanisms that are responsible for Aβ internalization in neurons and the links between Aβ internalization and neuronal dysfunction and death.

A brief description of Aβ uptake by glia is also presented.

American Psychological Association (APA)

Mohamed, Amany& Posse de Chaves, Elena. 2011. Aβ Internalization by Neurons and Glia. International Journal of Alzheimer's Disease،Vol. 2011, no. 2011, pp.1-17.
https://search.emarefa.net/detail/BIM-447851

Modern Language Association (MLA)

Mohamed, Amany& Posse de Chaves, Elena. Aβ Internalization by Neurons and Glia. International Journal of Alzheimer's Disease No. 2011 (2011), pp.1-17.
https://search.emarefa.net/detail/BIM-447851

American Medical Association (AMA)

Mohamed, Amany& Posse de Chaves, Elena. Aβ Internalization by Neurons and Glia. International Journal of Alzheimer's Disease. 2011. Vol. 2011, no. 2011, pp.1-17.
https://search.emarefa.net/detail/BIM-447851

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-447851