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Endothelial Function in a Mouse Model of Myeloperoxidase Deficiency
Joint Authors
Kjerrulf, Martin
Gan, Li-Ming
Nilsson, Holger
Golubinskaya, Veronika
Brandt-Eliasson, Ulla
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-22
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Myeloperoxidase (MPO) activity is suggested to reduce the function of vascular nitric oxide, thereby contributing to endothelial dysfunction, although data in rodents are inconclusive.
We examined vascular contractile and relaxant responses in MPO-deficient (MPO-/-) and wild-type mice to investigate the role for myeloperoxidase in the development of endothelial dysfunction.
Carotid and saphenous arteries were taken from 8-month-old mice and studied in a myograph.
Responses of carotid arteries to phenylephrine, high potassium, or acetylcholine (Ach) were statistically not different from controls.
Treatment with lipopolysaccharide (LPS; to enhance endothelial dysfunction) reduced responses to Ach in MPO-/- but did not affect responses in wild-type.
In response to high concentrations of Ach, carotid arteries responded with transient contractions, which were not different between the groups and not affected by LPS treatment.
Saphenous arteries from MPO-/- had smaller normalized diameters and developed less contractile force.
Vessels from MPO-/- were less sensitive to Ach than controls.
These data suggest that mature MPO-deficient mice do not show enhanced endothelial function compared to wild-type mice, even when provoked with LPS treatment.
The EDHF response appears to be reduced in MPO deficiency.
American Psychological Association (APA)
Golubinskaya, Veronika& Brandt-Eliasson, Ulla& Gan, Li-Ming& Kjerrulf, Martin& Nilsson, Holger. 2014. Endothelial Function in a Mouse Model of Myeloperoxidase Deficiency. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-447856
Modern Language Association (MLA)
Golubinskaya, Veronika…[et al.]. Endothelial Function in a Mouse Model of Myeloperoxidase Deficiency. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-447856
American Medical Association (AMA)
Golubinskaya, Veronika& Brandt-Eliasson, Ulla& Gan, Li-Ming& Kjerrulf, Martin& Nilsson, Holger. Endothelial Function in a Mouse Model of Myeloperoxidase Deficiency. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-447856
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-447856