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Holotranscobalamin Is a Useful Marker of Vitamin B12 Deficiency in Alcoholics
Joint Authors
Vitullo, Eustachio
Ciancio, Angela
Clemente, Rocco
Mannarella, Clara
Nuzzolese, Nicoletta
Fragasso, Alberto
Scarciolla, Oronzo
Sacco, Andrea
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-12
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Medicine
Information Technology and Computer Science
Abstract EN
Background.
Measurement of serum cobalamin (Cbl) levels is the standard investigation for assessing vitamin B12 deficiency.
Falsely increased values of Cbl can be caused by alcoholic liver disease.
Measurement of total vitamin B12 serum levels might be misleading in alcoholics, because a tissue metabolic deficiency is possible even with normal serum Cbl levels.
Holotranscobalamin (HoloTC), the Cbl metabolically active fraction, is considered as a better index of vitamin B12 deficiency.
Methods.
For assessing vitamin B12 status, we evaluated 22 adult alcoholic male patients by measuring in parallel serum Cbl, serum folate and red blood cell folate levels, HoloTC levels by the AxSYM assay.
Results.
HoloTC values were reduced in 3 alcoholics with borderline-low Cbl values.
Significant positive correlations were found between serum Cbl and HoloTC levels, serum Cbl and gamma-glutamyl transpeptidase (GGT).
Conclusion.
HoloTC measurement is a useful option for assessing vitamin B12 status in alcoholics, particularly in the subjects with borderline Cbl values and may be considered an early marker of vitamin B12 deficiency.
American Psychological Association (APA)
Fragasso, Alberto& Mannarella, Clara& Ciancio, Angela& Scarciolla, Oronzo& Nuzzolese, Nicoletta& Clemente, Rocco…[et al.]. 2012. Holotranscobalamin Is a Useful Marker of Vitamin B12 Deficiency in Alcoholics. The Scientific World Journal،Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-447871
Modern Language Association (MLA)
Fragasso, Alberto…[et al.]. Holotranscobalamin Is a Useful Marker of Vitamin B12 Deficiency in Alcoholics. The Scientific World Journal No. 2012 (2012), pp.1-4.
https://search.emarefa.net/detail/BIM-447871
American Medical Association (AMA)
Fragasso, Alberto& Mannarella, Clara& Ciancio, Angela& Scarciolla, Oronzo& Nuzzolese, Nicoletta& Clemente, Rocco…[et al.]. Holotranscobalamin Is a Useful Marker of Vitamin B12 Deficiency in Alcoholics. The Scientific World Journal. 2012. Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-447871
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-447871