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Melatonin Supplementation in Patients with Complete Tetraplegia and Poor Sleep
Joint Authors
Brown, Douglas J.
Armstrong, Stuart M.
Spong, Jo
Kennedy, Gerard A.
Berlowitz, David J.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-12
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
People with complete tetraplegia have interrupted melatonin production and commonly report poor sleep.
Whether the two are related is unclear.
This pilot study investigated whether nightly supplementation of 3 mg melatonin would improve objective and subjective sleep in tetraplegia.
Five participants with motor and sensory complete tetraplegia ingested 3 mg melatonin (capsule) two hours prior to usual sleep time for two weeks.
Full portable sleep studies were conducted in participants’ homes on the night before commencing melatonin supplementation (baseline) and on the last night of the supplementation period.
Endogenous melatonin levels were determined by assaying saliva samples collected the night of (just prior to sleep) and morning after (upon awakening) each sleep study.
Prior to each sleep study measures of state sleepiness and sleep behaviour were collected.
The results showed that 3 mg of melatonin increased salivary melatonin from near zero levels at baseline in all but one participant.
A delay in time to Rapid Eye Movement sleep, and an increase in stage 2 sleep were observed along with improved subjective sleep experience with a reduction in time to fall asleep, improved quality of sleep and fewer awakenings during the night reported.
Daytime sleepiness increased however.
A randomised, placebo controlled trial with a larger sample is required to further explore and confirm these findings.
American Psychological Association (APA)
Spong, Jo& Kennedy, Gerard A.& Brown, Douglas J.& Armstrong, Stuart M.& Berlowitz, David J.. 2013. Melatonin Supplementation in Patients with Complete Tetraplegia and Poor Sleep. Sleep Disorders،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-447872
Modern Language Association (MLA)
Spong, Jo…[et al.]. Melatonin Supplementation in Patients with Complete Tetraplegia and Poor Sleep. Sleep Disorders No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-447872
American Medical Association (AMA)
Spong, Jo& Kennedy, Gerard A.& Brown, Douglas J.& Armstrong, Stuart M.& Berlowitz, David J.. Melatonin Supplementation in Patients with Complete Tetraplegia and Poor Sleep. Sleep Disorders. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-447872
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-447872