Gender-Specific Neuroimmunoendocrine Response to Treadmill Exercise in 3xTg-AD Mice
Joint Authors
Cristofol, Rosa
Suñol, Cristina
Buccieri, Karla
Sanfeliu, Coral
Revilla, Susana
Giménez-Llort, Lydia
García, Yoelvis
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-10-12
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
The 3xTg-AD mouse develops a progressive Alzheimer's disease- (AD-) like brain pathology that causes cognitive- and neuropsychiatric-like symptoms of dementia.
Since its neuroimmunoendocrine axis is likewise impaired, this mouse is also useful for modelling complex age-related neurodegeneration.
This study analyzed behavioral, physiological, neurochemical, pathological and immunoendocrine alterations in male and female 3xTg-AD mice and assayed the effects of a short therapy of forced physical exercise at the moderate pathology stage of 6 months of age.
Gender effects were observed in most AD-related pathology and dysfunctions.
Five weeks of treadmill training produced beneficial effects, such as the reduction of brain oxidative stress and GABA-A receptor dysfunction in males and improvement of sensorimotor function in females.
In both sexes, exercise decreased the brain amyloid β 42/40 ratio levels.
The results highlight the importance of analyzing experimental therapies in both mouse model genders in order to improve our understanding of the disease and develop more appropriate therapies.
American Psychological Association (APA)
Giménez-Llort, Lydia& García, Yoelvis& Buccieri, Karla& Revilla, Susana& Suñol, Cristina& Cristofol, Rosa…[et al.]. 2010. Gender-Specific Neuroimmunoendocrine Response to Treadmill Exercise in 3xTg-AD Mice. International Journal of Alzheimer's Disease،Vol. 2010, no. 2010, pp.1-17.
https://search.emarefa.net/detail/BIM-447891
Modern Language Association (MLA)
Giménez-Llort, Lydia…[et al.]. Gender-Specific Neuroimmunoendocrine Response to Treadmill Exercise in 3xTg-AD Mice. International Journal of Alzheimer's Disease No. 2010 (2010), pp.1-17.
https://search.emarefa.net/detail/BIM-447891
American Medical Association (AMA)
Giménez-Llort, Lydia& García, Yoelvis& Buccieri, Karla& Revilla, Susana& Suñol, Cristina& Cristofol, Rosa…[et al.]. Gender-Specific Neuroimmunoendocrine Response to Treadmill Exercise in 3xTg-AD Mice. International Journal of Alzheimer's Disease. 2010. Vol. 2010, no. 2010, pp.1-17.
https://search.emarefa.net/detail/BIM-447891
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-447891