Genetic Rat Models of Parkinson's Disease

Joint Authors

Welchko, Ryan M.
Dunbar, Gary L.
Lévêque, Xavier T.

Source

International Journal of Alzheimer's Disease

Issue

Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2012-04-05

Country of Publication

Egypt

No. of Pages

6

Main Subjects

Diseases
Medicine

Abstract EN

Parkinson’s disease (PD) is a neurodegenerative disease characterized by a specific loss of dopaminergic neurons.

Although the vast majority of PD cases are idiopathic in nature, there is a subset that contains genetic links.

Of the genes that have been linked to PD, α-synuclein and leucine-rich repeat kinase 2 have been used to develop transgenic rat models of the disease.

In this paper we focused on the various transgenic rat models of PD in terms of their ability to mimic key symptoms of PD in a progressive manner.

In general, we found that most of these models provided useful tools for the early stages of PD, but the development of new transgenic rats that present significant neuropathologic and motoric deficits in a progressive manner that more accurately mimics PD is needed.

American Psychological Association (APA)

Welchko, Ryan M.& Lévêque, Xavier T.& Dunbar, Gary L.. 2012. Genetic Rat Models of Parkinson's Disease. International Journal of Alzheimer's Disease،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-447892

Modern Language Association (MLA)

Welchko, Ryan M.…[et al.]. Genetic Rat Models of Parkinson's Disease. International Journal of Alzheimer's Disease No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-447892

American Medical Association (AMA)

Welchko, Ryan M.& Lévêque, Xavier T.& Dunbar, Gary L.. Genetic Rat Models of Parkinson's Disease. International Journal of Alzheimer's Disease. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-447892

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-447892