An NTCP Analysis of Urethral Complications from Low Doserate Mono- and Bi-Radionuclide Brachytherapy
Joint Authors
Nahum, A. E.
Lucas, S.
Nuttens, V. E.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-07-06
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Urethral NTCP has been determined for three prostates implanted with seeds based on 125I (145 Gy), 103Pd (125 Gy), 131Cs (115 Gy), 103Pd-125I (145 Gy), or 103Pd-131Cs (115 Gy or 130 Gy).
First, DU20, meaning that 20% of the urhral volume receive a dose of at least DU20, is converted into an I-125 LDR equivalent DU20 in order to use the urethral NTCP model.
Second, the propagation of uncertainties through the steps in the NTCP calculation was assessed in order to identify the parameters responsible for large data uncertainties.
Two sets of radiobiological parameters were studied.
The NTCP results all fall in the 19%–23% range and are associated with large uncertainties, making the comparison difficult.
Depending on the dataset chosen, the ranking of NTCP values among the six seed implants studied changes.
Moreover, the large uncertainties on the fitting parameters of the urethral NTCP model result in large uncertainty on the NTCP value.
In conclusion, the use of NTCP model for permanent brachytherapy is feasible but it is essential that the uncertainties on the parameters in the model be reduced.
American Psychological Association (APA)
Nuttens, V. E.& Nahum, A. E.& Lucas, S.. 2011. An NTCP Analysis of Urethral Complications from Low Doserate Mono- and Bi-Radionuclide Brachytherapy. Prostate Cancer،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-447893
Modern Language Association (MLA)
Nuttens, V. E.…[et al.]. An NTCP Analysis of Urethral Complications from Low Doserate Mono- and Bi-Radionuclide Brachytherapy. Prostate Cancer No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-447893
American Medical Association (AMA)
Nuttens, V. E.& Nahum, A. E.& Lucas, S.. An NTCP Analysis of Urethral Complications from Low Doserate Mono- and Bi-Radionuclide Brachytherapy. Prostate Cancer. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-447893
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-447893