Anti-Hyperglycemic Properties of Crude Extract and Triterpenes from Poria cocos
Joint Authors
Chang, Cicero Lee-Tian
Hou, Chia-Chung
Yang, Wen-Chin
Li, Tzu-Hsuan
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-09-16
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Poria cocos, Bai Fu Ling in Chinese, is used in traditional Chinese medicine to treat diabetes.
However, its claimed benefits and mechanism are not fully understood.
This study aimed to investigate the effect and action of P.
cocos on type 2 diabetes.
We first performed phytochemical analysis on the crude extract and factions of P.
cocos.
P.
cocos crude extract at 50 mg/kg body weight or more significantly decreased blood glucose levels in db/db mice.
Based on a bioactivity-directed fractionation and isolation (BDFI) strategy, chloroform fraction and subfractions 4 and 6 of the P.
cocos crude extract possessed a blood glucose-lowering effect.
Dehydrotumulosic acid, dehydrotrametenolic acid, and pachymic acid were identified from the chloroform sub-fractions 4, 3, and 2, respectively.
Dehydrotumulosic acid had anti-hyperglycemic effect to a greater extent than dehydrotrametenolic acid and pachymic acid.
Mechanistic study on streptozocin- (STZ-) treated mice showed that the crude extract, dehydrotumulosic acid, dehydrotrametenolic acid, and pachymic acid of P.
cocos exhibited different levels of insulin sensitizer activity.
However, the P.
cocos crude extract and triterpenes appeared not to activate PPAR-γ pathway.
Overall, the data suggest that the P.
cocos extract and its triterpenes reduce postprandial blood glucose levels in db/db mice via enhanced insulin sensitivity irrespective of PPAR-γ.
American Psychological Association (APA)
Li, Tzu-Hsuan& Hou, Chia-Chung& Chang, Cicero Lee-Tian& Yang, Wen-Chin. 2010. Anti-Hyperglycemic Properties of Crude Extract and Triterpenes from Poria cocos. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-447900
Modern Language Association (MLA)
Li, Tzu-Hsuan…[et al.]. Anti-Hyperglycemic Properties of Crude Extract and Triterpenes from Poria cocos. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-447900
American Medical Association (AMA)
Li, Tzu-Hsuan& Hou, Chia-Chung& Chang, Cicero Lee-Tian& Yang, Wen-Chin. Anti-Hyperglycemic Properties of Crude Extract and Triterpenes from Poria cocos. Evidence-Based Complementary and Alternative Medicine. 2010. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-447900
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-447900