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Angiogenesis in Acute Myeloid Leukemia and Opportunities for Novel Therapies
Joint Authors
Trujillo, Angelica
McGee, Christie
Cogle, Christopher R.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-05
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Acute myeloid leukemia (AML) arises from neoplastic transformation of hematopoietic stem and progenitor cells, and relapsed disease remains one of the greater challenges in treating this hematologic malignancy.
This paper focuses on angiogenic aspects of AML including the significance and prognostic value of bone marrow microvessel density and circulating cytokine levels.
We show three general mechanisms whereby AML exploits angiogenic pathways, including direct induction of angiogenesis, paracrine regulation, and autocrine stimulation.
We also present early evidence that leukemia cells contribute directly to vascular endothelia.
Novel treatment strategies are proposed, and a review of relevant antiangiogenic clinical trials is presented.
By understanding how blood vessels can serve as a reservoir for refractory and relapsed AML, new diagnostics and promising treatment strategies can be developed.
American Psychological Association (APA)
Trujillo, Angelica& McGee, Christie& Cogle, Christopher R.. 2011. Angiogenesis in Acute Myeloid Leukemia and Opportunities for Novel Therapies. Journal of Oncology،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-447921
Modern Language Association (MLA)
Trujillo, Angelica…[et al.]. Angiogenesis in Acute Myeloid Leukemia and Opportunities for Novel Therapies. Journal of Oncology No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-447921
American Medical Association (AMA)
Trujillo, Angelica& McGee, Christie& Cogle, Christopher R.. Angiogenesis in Acute Myeloid Leukemia and Opportunities for Novel Therapies. Journal of Oncology. 2011. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-447921
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-447921