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Association between Micronutrients (Vitamin A, D, Iron) and Schistosome-Specific Cytokine Responses in Zimbabweans Exposed to Schistosoma haematobium
Joint Authors
Reilly, Liam
Mutapi, Francisca
Midzi, Nicholas
Nausch, Norman
Mduluza, Takafira
Source
Journal of Parasitology Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-20
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Micronutrients play an important role in the development of effective immune responses.
This study characterised a populations exposed to schistosome infections in terms of the relationship between micronutrients and immune responses.
Levels of retinol binding protein (RBP; vitamin A marker), vitamin D, ferritin and soluble transferrin receptor (sTfR), and C reactive protein (CRP) were related to levels of schistosome specific cytokines (IFN-γ, IL-4/5/10) in 40 Zimbabweans (7–54 years) exposed to Schistosoma haematobium infection.
67.2% of the participants were deficient in vitamin D.
RBP levels were within normal ranges but declined with age.
The two indicators of iron levels suggested that although levels of stored iron were within normal levels (normal ferritin levels), levels of functional iron (sTfR levels) were reduced in 28.6% of the population.
Schistosome infection alone was not associated with levels of any of the micronutrients, but altered the relationship between parasite-specific IL-4 and IL-5 and levels of ferritin and sTfR.
American Psychological Association (APA)
Reilly, Liam& Nausch, Norman& Midzi, Nicholas& Mduluza, Takafira& Mutapi, Francisca. 2012. Association between Micronutrients (Vitamin A, D, Iron) and Schistosome-Specific Cytokine Responses in Zimbabweans Exposed to Schistosoma haematobium. Journal of Parasitology Research،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-447927
Modern Language Association (MLA)
Reilly, Liam…[et al.]. Association between Micronutrients (Vitamin A, D, Iron) and Schistosome-Specific Cytokine Responses in Zimbabweans Exposed to Schistosoma haematobium. Journal of Parasitology Research No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-447927
American Medical Association (AMA)
Reilly, Liam& Nausch, Norman& Midzi, Nicholas& Mduluza, Takafira& Mutapi, Francisca. Association between Micronutrients (Vitamin A, D, Iron) and Schistosome-Specific Cytokine Responses in Zimbabweans Exposed to Schistosoma haematobium. Journal of Parasitology Research. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-447927
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-447927