Iron and Neurodegeneration : From Cellular Homeostasis to Disease
Joint Authors
Batista-Nascimento, Liliana
Rodrigues-Pousada, Claudina
Pimentel, Catarina
Andrade Menezes, Regina
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-30
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Accumulation of iron (Fe) is often detected in the brains of people suffering from neurodegenerative diseases.
High Fe concentrations have been consistently observed in Parkinson’s, Alzheimer’s, and Huntington’s diseases; however, it is not clear whether this Fe contributes to the progression of these diseases.
Other conditions, such as Friedreich’s ataxia or neuroferritinopathy are associated with genetic factors that cause Fe misregulation.
Consequently, excessive intracellular Fe increases oxidative stress, which leads to neuronal dysfunction and death.
The characterization of the mechanisms involved in the misregulation of Fe in the brain is crucial to understand the pathology of the neurodegenerative disorders and develop new therapeutic strategies.
Saccharomyces cerevisiae, as the best understood eukaryotic organism, has already begun to play a role in the neurological disorders; thus it could perhaps become a valuable tool also to study the metalloneurobiology.
American Psychological Association (APA)
Batista-Nascimento, Liliana& Pimentel, Catarina& Andrade Menezes, Regina& Rodrigues-Pousada, Claudina. 2012. Iron and Neurodegeneration : From Cellular Homeostasis to Disease. Oxidative Medicine and Cellular Longevity،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-447929
Modern Language Association (MLA)
Batista-Nascimento, Liliana…[et al.]. Iron and Neurodegeneration : From Cellular Homeostasis to Disease. Oxidative Medicine and Cellular Longevity No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-447929
American Medical Association (AMA)
Batista-Nascimento, Liliana& Pimentel, Catarina& Andrade Menezes, Regina& Rodrigues-Pousada, Claudina. Iron and Neurodegeneration : From Cellular Homeostasis to Disease. Oxidative Medicine and Cellular Longevity. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-447929
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-447929