Paradoxical Roles of Tumour Necrosis Factor-Alpha in Prostate Cancer Biology
Joint Authors
Russell, Pamela J.
Tse, Brian W. C.
Scott, Kieran F.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-27
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Tumour necrosis factor (TNF) is a pleiotropic cytokine with dual roles in cancer biology including prostate cancer (PCa).
On the one hand, there is evidence that it stimulates tumour angiogenesis, is involved in the initiation of PCa from an androgen-dependent to a castrate resistant state, plays a role in epithelial to mesenchymal plasticity, and may contribute to the aberrant regulation of eicosanoid pathways.
On the other hand, TNF has also been reported to inhibit neovascularisation, induce apoptosis of PCa cells, and stimulate antitumour immunity.
Much of the confusion surrounding its seemingly paradoxical roles in cancer biology stems from the dependence of its effects on the biological model within which TNF is investigated.
This paper will address some of these issues and also discuss the therapeutic implications.
American Psychological Association (APA)
Tse, Brian W. C.& Scott, Kieran F.& Russell, Pamela J.. 2012. Paradoxical Roles of Tumour Necrosis Factor-Alpha in Prostate Cancer Biology. Prostate Cancer،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-447945
Modern Language Association (MLA)
Tse, Brian W. C.…[et al.]. Paradoxical Roles of Tumour Necrosis Factor-Alpha in Prostate Cancer Biology. Prostate Cancer No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-447945
American Medical Association (AMA)
Tse, Brian W. C.& Scott, Kieran F.& Russell, Pamela J.. Paradoxical Roles of Tumour Necrosis Factor-Alpha in Prostate Cancer Biology. Prostate Cancer. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-447945
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-447945