Human Coronaviruses HCoV-NL63 and HCoV-HKU1 in Hospitalized Children with Acute Respiratory Infections in Beijing, China
Joint Authors
Lu, Rou-Jian
Zhou, Wei-Min
Tan, Wen-Jie
Ma, Xue-Jun
Xie, Zheng-De
Ruan, Li
Cui, Li-Jin
Zhang, Chen
Liu, Chuan-Yan
Zhang, Ling-Lin
Zhang, Ting
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-07-21
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The human coronaviruses (HCoVs) HCoV-NL63 and HCoV-HKU1 are two recently discovered coronaviruses that circulate widely and are associated with acute respiratory infections (ARI).
We detected HCoV-NL63 and HCoV-HKU1 in specimens collected from May 2008 to March 2010 from patients with ARI aged <7.75 years of age attending the Beijing Children's Hospital.
Thirty-two (8.4%) and 57 (14.9%) of 382 specimens tested positive for HCoV-NL63 and HCoV-HKU1, respectively, by real-time RT-PCR.
Use of a Luminex xTAG RVP Fast kit showed that coinfection with respiratory syncytial virus and parainfluenza 3 virus was common among patients infected with either virus type.
In HCoV-HKU1-infected patients, the predominant clinical symptoms were cough, fever, and expectoration.
In HCoV-NL63-infected patients they were cough, fever, and rhinorrhea.
Phylogenetic studies showed that the HCoV-HKU1 nucleoprotein gene was relatively conserved compared to NCBI reference sequences, while the 1ab gene of HCoV-NL63 showed more variation.
American Psychological Association (APA)
Cui, Li-Jin& Zhang, Chen& Zhang, Ting& Lu, Rou-Jian& Xie, Zheng-De& Zhang, Ling-Lin…[et al.]. 2011. Human Coronaviruses HCoV-NL63 and HCoV-HKU1 in Hospitalized Children with Acute Respiratory Infections in Beijing, China. Advances in Virology،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-447958
Modern Language Association (MLA)
Cui, Li-Jin…[et al.]. Human Coronaviruses HCoV-NL63 and HCoV-HKU1 in Hospitalized Children with Acute Respiratory Infections in Beijing, China. Advances in Virology No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-447958
American Medical Association (AMA)
Cui, Li-Jin& Zhang, Chen& Zhang, Ting& Lu, Rou-Jian& Xie, Zheng-De& Zhang, Ling-Lin…[et al.]. Human Coronaviruses HCoV-NL63 and HCoV-HKU1 in Hospitalized Children with Acute Respiratory Infections in Beijing, China. Advances in Virology. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-447958
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-447958