Human Coronaviruses HCoV-NL63 and HCoV-HKU1 in Hospitalized Children with Acute Respiratory Infections in Beijing, China

Joint Authors

Lu, Rou-Jian
Zhou, Wei-Min
Tan, Wen-Jie
Ma, Xue-Jun
Xie, Zheng-De
Ruan, Li
Cui, Li-Jin
Zhang, Chen
Liu, Chuan-Yan
Zhang, Ling-Lin
Zhang, Ting

Source

Advances in Virology

Issue

Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2011-07-21

Country of Publication

Egypt

No. of Pages

6

Main Subjects

Biology

Abstract EN

The human coronaviruses (HCoVs) HCoV-NL63 and HCoV-HKU1 are two recently discovered coronaviruses that circulate widely and are associated with acute respiratory infections (ARI).

We detected HCoV-NL63 and HCoV-HKU1 in specimens collected from May 2008 to March 2010 from patients with ARI aged <7.75 years of age attending the Beijing Children's Hospital.

Thirty-two (8.4%) and 57 (14.9%) of 382 specimens tested positive for HCoV-NL63 and HCoV-HKU1, respectively, by real-time RT-PCR.

Use of a Luminex xTAG RVP Fast kit showed that coinfection with respiratory syncytial virus and parainfluenza 3 virus was common among patients infected with either virus type.

In HCoV-HKU1-infected patients, the predominant clinical symptoms were cough, fever, and expectoration.

In HCoV-NL63-infected patients they were cough, fever, and rhinorrhea.

Phylogenetic studies showed that the HCoV-HKU1 nucleoprotein gene was relatively conserved compared to NCBI reference sequences, while the 1ab gene of HCoV-NL63 showed more variation.

American Psychological Association (APA)

Cui, Li-Jin& Zhang, Chen& Zhang, Ting& Lu, Rou-Jian& Xie, Zheng-De& Zhang, Ling-Lin…[et al.]. 2011. Human Coronaviruses HCoV-NL63 and HCoV-HKU1 in Hospitalized Children with Acute Respiratory Infections in Beijing, China. Advances in Virology،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-447958

Modern Language Association (MLA)

Cui, Li-Jin…[et al.]. Human Coronaviruses HCoV-NL63 and HCoV-HKU1 in Hospitalized Children with Acute Respiratory Infections in Beijing, China. Advances in Virology No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-447958

American Medical Association (AMA)

Cui, Li-Jin& Zhang, Chen& Zhang, Ting& Lu, Rou-Jian& Xie, Zheng-De& Zhang, Ling-Lin…[et al.]. Human Coronaviruses HCoV-NL63 and HCoV-HKU1 in Hospitalized Children with Acute Respiratory Infections in Beijing, China. Advances in Virology. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-447958

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-447958